Aminoacyl RNA domain of turnip yellow mosaic virus Val-RNA interacting with elongation factor Tu.

Nucleic Acids Research
R L JoshiA L Haenni

Abstract

Turnip yellow mosaic virus (TYMV) Val-RNA forms a complex with the peptide elongation factor Tu (EF-Tu) in the presence of GTP: the Val-RNA is protected by EF-Tu.GTP from non-enzymatic deacylation and nuclease digestion. The determination of the length of the shortest TYMV Val-RNA fragment that binds EF-Tu.GTP leads us to conclude that the valylated aminoacyl RNA domain equivalent in tRNAs to the continuous helix formed by the acceptor stem and the T arm is sufficient for complex formation. Since the aminoacyl RNA domain is also sufficient for adenylation by the ATP(CTP):tRNA nucleotidyltransferase, an analogy can be drawn between these two tRNA-specific proteins.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D A Peattie
Aug 1, 1977·Nucleic Acids Research·H Donis-KellerW Gilbert
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Dec 1, 1981·European Journal of Biochemistry·K GulewiczM Sprinzl

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Citations

Oct 15, 1991·European Journal of Biochemistry·R M MansL Bosch
Jan 5, 1992·Journal of Molecular Biology·W Q Li, M Yarus
Mar 6, 1998·Molecular and Cellular Biology·H J DrabkinU L Rajbhandary
Jun 1, 1994·Trends in Biochemical Sciences·M Sprinzl
Aug 3, 1993·Biochemistry·K M HarringtonO C Uhlenbeck

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