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Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World

FEBS Letters

Feb 2, 2016

Hieronim Jakubowski

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Abstract

Coded peptide synthesis must have been preceded by a prebiotic stage, in which thioesters played key roles. Fossils of the Thioester World are found in extant aminoacyl-tRNA synthetases (AARSs). Indeed, studies of the editing function reveal that AARSs have a thiol-binding site in their...read more

Mentioned in this Paper

Amino Acyl-tRNA Synthetases
Study
Thioester Biosynthetic Process
Triplet Codon-amino Acid Adaptor Activity
Genome
Coenzymes
Chemical Bond
Sulfur
Transfer RNA
Sulfhydryl Compounds
Paper Details
References
  • References65
  • Citations3
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Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World

FEBS Letters

Feb 2, 2016

Hieronim Jakubowski

PMID: 26831912

DOI: 10.1002/1873-3468.12085

Abstract

Coded peptide synthesis must have been preceded by a prebiotic stage, in which thioesters played key roles. Fossils of the Thioester World are found in extant aminoacyl-tRNA synthetases (AARSs). Indeed, studies of the editing function reveal that AARSs have a thiol-binding site in their...read more

Mentioned in this Paper

Amino Acyl-tRNA Synthetases
Study
Thioester Biosynthetic Process
Triplet Codon-amino Acid Adaptor Activity
Genome

Related Papers

Paper Details
References
  • References65
  • Citations3
12345...

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