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Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World

FEBS Letters

Feb 3, 2016

Hieronim Jakubowski

Abstract

Coded peptide synthesis must have been preceded by a prebiotic stage, in which thioesters played key roles. Fossils of the Thioester World are found in extant aminoacyl-tRNA synthetases (AARSs). Indeed, studies of the editing function reveal that AARSs have a thiol-binding site in their...read more

Mentioned in this Paper

Chemical Bond
Study
Thioester Biosynthetic Process
Activation of Amino Acids
Coenzyme A Metabolic Process
Genome
Peptide Biosynthesis
Coenzyme A
Thioester
MT-TA gene
Paper Details
References

Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World

FEBS Letters

Feb 3, 2016

Hieronim Jakubowski

PMID: 26831912

DOI: 10.1002/1873-3468.12085

Abstract

Coded peptide synthesis must have been preceded by a prebiotic stage, in which thioesters played key roles. Fossils of the Thioester World are found in extant aminoacyl-tRNA synthetases (AARSs). Indeed, studies of the editing function reveal that AARSs have a thiol-binding site in their...read more

Mentioned in this Paper

Chemical Bond
Study
Thioester Biosynthetic Process
Activation of Amino Acids
Coenzyme A Metabolic Process
Genome
Peptide Biosynthesis
Coenzyme A
Thioester
MT-TA gene

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Paper Details
References
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