Aminocaproic acid administration is associated with reduced perioperative blood loss and transfusion in pediatric craniofacial surgery

Acta Anaesthesiologica Scandinavica
G HsuPaul A Stricker

Abstract

Severe blood loss is a common complication of craniofacial reconstruction surgery. The antifibrinolytic ε-aminocaproic acid (EACA) reduces transfusion requirements in children undergoing cardiac surgery and in older children undergoing spine surgery. Tranexamic acid (TXA), another antifibrinolytic with a similar mechanism of action, has been shown to reduce blood loss and transfusion requirements in children undergoing craniofacial surgery. However, TXA has been associated with an increase in post-operative seizures and is more expensive than EACA. There is currently little published data evaluating the efficacy of EACA in children undergoing craniofacial surgery. This is a retrospective study of prospectively collected data from our craniofacial perioperative registries for children under 6 years of age who underwent anterior or posterior cranial vault reconstruction. We compared calculated blood loss, blood donor exposures, and post-operative drain output between subjects who received EACA and those who did not. The registry queries returned data from 152 subjects. Eighty-six did not receive EACA and 66 received EACA. The EACA group had significantly lower calculated blood loss (82 ± 43 vs. 106 ± 63 ml/kg, P = 0.01), fewer in...Continue Reading

References

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May 13, 2014·Paediatric Anaesthesia·Susan M Goobie, Thorsten Haas

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Citations

Feb 18, 2017·Paediatric Anaesthesia·Susan M GoobieUNKNOWN the Pediatric Craniofacial Collaborative Group
Mar 31, 2017·The Journal of Craniofacial Surgery·Princy ThottathilPaul A Stricker
Nov 6, 2018·The Journal of Craniofacial Surgery·Victor M LuDavid J Daniels
Jul 2, 2019·The Journal of Craniofacial Surgery·Wallis T MuhlyPaul A Stricker
Feb 23, 2019·Journal of Pediatric Orthopedics. Part B·Elizabeth B GausdenPeter D Fabricant
May 26, 2018·Plastic and Reconstructive Surgery·Stav BrownPeter J Taub
Feb 16, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Patrick G FernandezUNKNOWN Pediatric Craniofacial Collaborative Group
Feb 11, 2021·Anesthesiology Clinics·Nicholas Meier
Mar 5, 2021·Facial Plastic Surgery & Aesthetic Medicine·Rao FuRu-Lin Huang
Aug 15, 2020·Anesthesiology Clinics·David Preston, Aditee Ambardekar

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