PMID: 6965311Jan 4, 1980Paper

Aminocaproic acid. Use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia

JAMA : the Journal of the American Medical Association
F H Gardner, R E Helmer

Abstract

The bleeding complications of some forms of thrombocytopenia are difficult to control. Many patients become refractory to platelet transfusions even when HLA-matched. We have successfully used aminocaproic acid to control bleeding in 13 patients with amegakaryocytic thrombocytopenia. Four patients receiving long-term therapy with this drug had striking reductions in the number of platelet transfusions required for capillary bleeding. No adverse effects have been noted save for orthostatic hypotension, which is ameliorated by a reduction in dosage. Quantitative platelet function changes have been impossible to demonstrate, but no changes were noted in four patients with normal platelet counts who were receiving high-dose aminocaproic acid for treatment of subarachnoid hemorrhage. Aminocaproic acid has proved to be a valuable agent in the management of patients with amegakaryocytic thrombocytopenia, especially in decreasing the need for platelet transfusions.

Citations

Nov 1, 1990·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·I H Valdez, L L Patton
Jul 20, 2007·Acta chirurgica Iugoslavica·D VucelićB Spica
Dec 1, 1990·Australian and New Zealand Journal of Medicine·J Randall, K Taylor
Feb 15, 2007·Journal of Palliative Medicine·Michael E SalaczDavid E Weissman
Jul 23, 1998·The New England Journal of Medicine·P M Mannucci
Mar 1, 1987·British Journal of Haematology·F H Gardner, H S Juneja
Jun 1, 1994·The Journal of the Association of Physicians of India·V D CharanV P Choudhry
Oct 1, 1990·Transfusion Medicine Reviews·T S Kickler
Oct 11, 2015·Carbohydrate Polymers·Dharmesh R ChejaraViness Pillay
Aug 2, 2006·Journal of Thrombosis and Haemostasis : JTH·J N George
Jul 22, 2015·British Journal of Haematology·Simon J StanworthJudith Marsh
Jun 1, 1987·Blood Reviews·H D Preisler
Feb 3, 2015·Hematological Oncology·Ariela MarshallWalter Dzik
Mar 6, 2003·Vox Sanguinis·Paul M Ness
Oct 24, 2002·Current Opinion in Hematology·Jason ChiuThomas J Reid
Jan 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·L Juillerat-JeanneretJ P Bargetzi

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