PMID: 690002Jul 1, 1978Paper

Aminoglycoside antibiotics. XII. Effect of N-alkylation in kanamycin antibiotics

The Journal of Antibiotics
S NakagawaH Kawaguchi

Abstract

Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.

Related Concepts

Alkylation
Antibiotic Resistance, Microbial
Kantrex
Structure-Activity Relationship

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