Aminoglycoside-modifying enzyme content of a multiply resistant strain of Streptococcus faecalis

The Journal of Antimicrobial Chemotherapy
T CombesP Courvalin

Abstract

Streptococcus faecalis strain BM6217 was resistant to high levels of all the clinically useful aminoglycoside antibiotics. This broad aminoglycoside resistance was mediated by constitutively synthesized phosphotransferase, acetyltransferase, and adenylyltransferase activities. It was inferred that phosphorylation occurred at the 3', 5", and 2"-hydroxyl groups, acetylation at the 6'-amino group, and adenylylation, probably, at the 6-hydroxyl group of the aminoglycosides. Strain BM6217 remained susceptible to the aminocyclitol spectinomycin but the combination of penicillin G with that antibiotic appeared antagonistic to this strain.

Citations

Feb 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G M Eliopoulos, C T Eliopoulos
Jun 1, 1983·Antimicrobial Agents and Chemotherapy·B E MurrayJ Panida
Oct 1, 1988·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
Nov 1, 1990·Antimicrobial Agents and Chemotherapy·H OunissiP Courvalin
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·S L Hodel-Christian, B E Murray
Jul 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S H HartzenJ J Andreasen
Jan 1, 1990·Clinical Microbiology Reviews·B E Murray

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