Abstract
Resistance to gentamicin in Escherichia coli from blood culture has shown an increase over the past decade in Norway. This study was done to investigate aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae in Western Norway. The material included 49 blood culture isolates which had shown aminoglycoside resistance collected during 2000-2009. To investigate co-resistance to alternative antibiotics and dynamics involved in aminoglycoside resistance 67 isolates (mostly from urine) exhibiting resistance to both aminoglycosides and extended spectrum beta-lactam antibiotics were also included. MIC values were obtained for amikacin, gentamicin, kanamycin, netilmicin, streptomycin and tobramycin and all isolates were screened using PCR for aac(3)-II and aac(6')-Ib, encoding aminoglycoside modifying enzymes. Resistance to ≥3 aminoglycosides was found in 92% of the isolates and 60.3% showed resistance to gentamicin, netilmicin, tobramycin and kanamycin. Amikacin resistance was low. Co-resistance to ciprofloxacin was found in 88% of the isolates with gentamicin resistance. aac(3)-IIa/c was found in 79.3% and aac(6')-Ib in 37.9% of the isolates and 28.4% harboured both genes. aac(6')-Ib-cr, possibly contributing to ciprof...Continue Reading
References
Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·D M LivermoreK P Shannon
Nov 13, 2004·Molecular Nutrition & Food Research·Sybille BoehmeWolfgang Witte
Nov 11, 2005·International Journal of Antimicrobial Agents·Po-Ren HsuehKwen-Tay Luh
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Ying-Tsong ChenTsai-Ling Lauderdale
Sep 7, 2006·Antimicrobial Agents and Chemotherapy·Chi Hye ParkDavid C Hooper
Aug 20, 2008·Biochemistry·Matthew W VettingJohn S Blanchard
Sep 25, 2008·The Journal of Antimicrobial Chemotherapy·Ping ShenLanjuan Li
Feb 17, 2009·Diagnostic Microbiology and Infectious Disease·Soo-Young KimKyungja Han
Mar 17, 2010·Diagnostic Microbiology and Infectious Disease·Nabil KarahUNKNOWN Norwegian Study Group on PMQR
Jun 16, 2010·International Journal of Medical Microbiology : IJMM·Elena RuizCarmen Torres
Sep 14, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Maria S Ramirez, Marcelo E Tolmasky
Oct 5, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·José Manuel Rodríguez-MartínezAlvaro Pascual
Nov 16, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Po-Ren HsuehLee-Jene Teng
Citations
Dec 5, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Elisenda MiróFerran Navarro
Nov 30, 2013·International Journal of Environmental Research and Public Health·Nerino AllocatiCarmine Di Ilio
Nov 16, 2013·Diagnostic Microbiology and Infectious Disease·Bjørg C HaldorsenUNKNOWN Norwegian Study Group on Aminoglycoside Resistance
Jul 23, 2014·Laboratory Medicine·Shahin Najar PeerayehSafura Derakhshan
Nov 3, 2015·American Journal of Infection Control·Alix PantelJean-Philippe Lavigne
Nov 2, 2012·Scandinavian Journal of Infectious Diseases·Åse Östholm BalkhedLennart E Nilsson
May 21, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Øyvind KommedalPaul Christoffer Lindemann
Jun 24, 2017·FEMS Microbiology Letters·Kuastros Mekonnen BelayneheHan Sang Yoo
Aug 15, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Soumia BrahmiJean-Philippe Lavigne
May 29, 2014·Antimicrobial Agents and Chemotherapy·Reem AlmaghrabiM Hong Nguyen
Jun 15, 2016·Antimicrobial Agents and Chemotherapy·Ghady HaidarM Hong Nguyen
Jun 5, 2019·PloS One·Beata MaczynskaMarzenna Bartoszewicz
Mar 3, 2020·PLoS Computational Biology·Jason C HyunBernhard O Palsson
Sep 24, 2019·Frontiers in Veterinary Science·Véronique DupouyAlain Bousquet-Mélou
Apr 25, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Amel AbderrahimAlix Pantel
May 5, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marta Fernández-MartínezUNKNOWN Spanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)
Nov 12, 2019·The Journal of Arthroplasty·Jae Hoo LeeKwan Kyu Park
May 5, 2021·Expert Review of Anti-infective Therapy·Irene GalaniHelen Giamarellou