Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Paul Christoffer LindemannHaima Mylvaganam

Abstract

Resistance to gentamicin in Escherichia coli from blood culture has shown an increase over the past decade in Norway. This study was done to investigate aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae in Western Norway. The material included 49 blood culture isolates which had shown aminoglycoside resistance collected during 2000-2009. To investigate co-resistance to alternative antibiotics and dynamics involved in aminoglycoside resistance 67 isolates (mostly from urine) exhibiting resistance to both aminoglycosides and extended spectrum beta-lactam antibiotics were also included. MIC values were obtained for amikacin, gentamicin, kanamycin, netilmicin, streptomycin and tobramycin and all isolates were screened using PCR for aac(3)-II and aac(6')-Ib, encoding aminoglycoside modifying enzymes. Resistance to ≥3 aminoglycosides was found in 92% of the isolates and 60.3% showed resistance to gentamicin, netilmicin, tobramycin and kanamycin. Amikacin resistance was low. Co-resistance to ciprofloxacin was found in 88% of the isolates with gentamicin resistance. aac(3)-IIa/c was found in 79.3% and aac(6')-Ib in 37.9% of the isolates and 28.4% harboured both genes. aac(6')-Ib-cr, possibly contributing to ciprof...Continue Reading

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Mar 17, 2010·Diagnostic Microbiology and Infectious Disease·Nabil KarahUNKNOWN Norwegian Study Group on PMQR
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Citations

Dec 5, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Elisenda MiróFerran Navarro
Nov 30, 2013·International Journal of Environmental Research and Public Health·Nerino AllocatiCarmine Di Ilio
Nov 16, 2013·Diagnostic Microbiology and Infectious Disease·Bjørg C HaldorsenUNKNOWN Norwegian Study Group on Aminoglycoside Resistance
Jul 23, 2014·Laboratory Medicine·Shahin Najar PeerayehSafura Derakhshan
Nov 3, 2015·American Journal of Infection Control·Alix PantelJean-Philippe Lavigne
May 21, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Øyvind KommedalPaul Christoffer Lindemann
Aug 15, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Soumia BrahmiJean-Philippe Lavigne
Apr 25, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Amel AbderrahimAlix Pantel
May 5, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marta Fernández-MartínezUNKNOWN Spanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH)

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