Aminoglycosides Monotherapy as First-Line Treatment for Febrile Urinary Tract Infection in Children

The Pediatric Infectious Disease Journal
Nora PoeyRobert Cohen

Abstract

We report a retrospective monocentric descriptive study performed in CHI Creteil for 20 months to describe the management and outcome of amikacin monotherapy as an alternative to third-generation cephalosporins for empiric treatment of febrile urinary tract infection (FUTI) in children. Data were analyzed for 151 children, and 90 selected cases were classified as certain or highly probable FUTI. Escherichia coli infection was found in 89 cases. In all patients, fever was resolved within 72 hours after beginning amikacin treatment. Only 5.3% of children were febrile after 48 hours. The mean amikacin treatment duration was 3.05 ± 0.13 days before oral treatment began (guided by antibiotic susceptibility testing). Amikacin monotherapy seems effective for the initial management of FUTI in children.

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Citations

Aug 17, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle MahonySean E Kennedy
Aug 28, 2019·Acta Paediatrica·Anita AmmentiUNKNOWN Italian Society of Pediatric Nephrology
Dec 29, 2018·Recent Patents on Inflammation & Allergy Drug Discovery·Alexander K C LeungKam L Hon
Jul 18, 2020·The Pediatric Infectious Disease Journal·Robert CohenStéphane Bonacorsi
May 4, 2020·Médecine et maladies infectieuses·J WickyB Demoré

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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