PMID: 7541282Apr 1, 1995Paper

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

British Journal of Pharmacology
C C WuJ R Vane

Abstract

1. We have investigated the effects of aminoguanidine, a relatively selective inhibitor of the cytokine-inducible isoform of nitric oxide synthase (iNOS), on the delayed circulatory failure, vascular hyporeactivity to vasoconstrictor agents, and iNOS activity in a rat model of circulatory shock induced by bacterial endotoxin (E. coli lipopolysaccharide; LPS). In addition, we have evaluated the effect of aminoguanidine on the 24 h survival rate in a murine model of endotoxaemia. 2. Male Wistar rats were anaesthetized and instrumented for the measurement of mean arterial blood pressure (MAP) and heart rate (HR). Injection of LPS (10 mg kg-1, i.v.) resulted in a fall in MAP from 115 +/- 4 mmHg (time 0, control) to 79 +/- 9 mmHg at 180 min (P < 0.05, n = 10). The pressor effect of noradrenaline (NA, 1 microgram kg-1, i.v.) was also significantly reduced at 60, 120 and 180 min after LPS injection. In contrast, animals pretreated with aminoguanidine (15 mg kg-1, i.v., 20 min prior to LPS injection) maintained a significantly higher MAP (at 180 min, 102 +/- 3 mmHg, n = 10, P < 0.05) when compared to rats given only LPS (LPS-rats). Cumulative administration of aminoguanidine (15 mg kg-1 and 45 mg kg-1) given 180 min after LPS caused a ...Continue Reading

References

Nov 1, 1992·The Journal of Clinical Investigation·P J Shultz, L Raij
Jun 3, 1992·Journal of the National Cancer Institute·R G Kilbourn, O W Griffith
Jan 1, 1992·Cardiovascular Research·C E WrightS Moncada
Dec 1, 1990·British Journal of Pharmacology·I R HutchesonN K Boughton-Smith
Mar 30, 1990·Biochemical and Biophysical Research Communications·M HeckerJ R Vane
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Jan 1, 1985·The Biochemical Journal·N SeilerB Knödgen
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 2, 1993·European Journal of Pharmacology·K HasanR G Tilton
Nov 1, 1993·British Journal of Pharmacology·M J GriffithsT W Evans
Nov 30, 1993·European Journal of Pharmacology·C SzabóJ R Vane
Jan 1, 1994·Advances in Pharmacology·C Thiemermann
Mar 16, 1993·European Journal of Pharmacology·T P MiskoM G Currie

❮ Previous
Next ❯

Citations

Sep 26, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Y LiY A Ding
Aug 24, 2006·Digestive Diseases and Sciences·Kenneth S HelmerDavid W Mercer
Jun 1, 2005·The Journal of Surgical Research·Anthony W ViolL D Britt
Feb 21, 2004·Medical Hypotheses·Alper B Iskit, M Oguz Guc
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Aug 12, 1999·European Journal of Pharmacology·J C StocletA L Kleschyov
Dec 18, 2001·Pharmacology & Therapeutics·F FeihlL Liaudet
Aug 1, 1997·General Pharmacology·C Thiemermann
Feb 1, 1997·British Journal of Pharmacology·B Y De WinterP A Pelckmans
Jan 10, 1998·British Journal of Pharmacology·L LiaudetF Feihl
Aug 26, 1998·The British Journal of Surgery·B KavukluI Sayek
Apr 12, 2000·The British Journal of Surgery·B KavukluI Sayek
Mar 17, 2001·Clinical and Experimental Pharmacology & Physiology·R P LeeH I Chen
Nov 1, 1996·Critical Care Medicine·M P Fink
Jul 11, 1998·Critical Care Medicine·C M Pastor, P M Suter
Mar 13, 1999·Critical Care Medicine·M Hirokawa, M Walser
Oct 16, 2004·Critical Care Medicine·Yvette C LuikingNicolaas E Deutz
Mar 1, 2006·Critical Care Medicine·Hsing I ChenShang-Jyh Kao
Oct 17, 1998·Acta Anaesthesiologica Scandinavica·K MetcalfB Lisander
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·H J HongM H Yen
Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Demeral D LiuHsing I Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.