Aminoguanidine-provoked leukocyte adherence to rat mesenteric venules: role of constitutive nitric oxide synthase inhibition

British Journal of Pharmacology
J Lopez-Belmonte, B J Whittle

Abstract

1. The effects of aminoguanidine on neutrophil adherence to venules and on the diameter of arterioles in the mesenteric vascular bed of the pentobarbitone-anaesthetized rat have been compared with those of the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). 2. Administration of L-NAME (1-10 mg kg-1, i.v.) caused a dose-dependent increase in leukocyte adherence and a reduction in leukocyte rolling velocity in postcapillary venules of the rat mesentery over 1 h. 3. Likewise, aminoguanidine (10-100 mg kg-1, i.v.) dose-dependently increased leukocyte adherence and decreased leukocyte rolling velocity over 1 h. 4. Both L-NAME and aminoguanidine caused a dose-dependent reduction in mesenteric arteriolar diameter and an increase in systemic arterial blood pressure. 5. The effects of aminoguanidine (50 mg kg-1, i.v.) on leukocyte adherence, arteriolar diameter and on blood pressure were significantly reversed by pretreatment with L-arginine (300 mg kg-1, i.v.). 6. These findings indicate that, like L-NAME, aminoguanidine can acutely promote leukocyte adherence to the mesenteric venular wall and reduce arteriolar diameter. Moreover, these acute effects were reversed by L-arginine, suggesting they are mediated...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P M BathJ F Martin
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Sep 1, 1980·Journal of Pharmacological Methods·D C Cardinal, G A Higgs
Nov 2, 1993·European Journal of Pharmacology·K HasanR G Tilton
Nov 1, 1993·British Journal of Pharmacology·N K Boughton-SmithS Moncada
Nov 1, 1993·British Journal of Pharmacology·M J GriffithsT W Evans
Jun 1, 1995·British Journal of Pharmacology·F LászlóS Moncada
Mar 16, 1993·European Journal of Pharmacology·T P MiskoM G Currie
Oct 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P KubesJ P Gaboury

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Citations

Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Georg BerndtHenning Schröder
Oct 13, 1998·The Annals of Thoracic Surgery·P E ParrinoI L Kron
Jan 16, 2002·European Journal of Pharmacology·U Burcin IsmailogluMustafa Ilhan
May 20, 1998·European Journal of Pharmacology·S KennedyC L Wainwright
Aug 25, 1999·The British Journal of Surgery·S C WeightM L Nicholson
Jun 24, 2004·Infection and Immunity·Kara L Cummings, Rick L Tarleton
Apr 2, 2002·Expert Opinion on Investigational Drugs·Emaad Abdel-Rahman, W Kline Bolton
Mar 1, 2006·Nitric Oxide : Biology and Chemistry·Elisabetta BarocelliMariannina Impicciatore
May 25, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Georg BerndtHenning Schröder
Aug 26, 2011·European Journal of Pharmacology·Vinicius F CarvalhoPatrícia M R E Silva
Sep 11, 2018·Journal of Leukocyte Biology·Tassia SantoroVinicius F Carvalho
Feb 4, 1998·Hypertension·D L MattsonA W Cowley

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