Abstract
To investigate the anti-inflammatory effect of an adenosine monophosphate (AMP) analog, aminoimidazole carboxamide ribonucleotide (AICAR), in experimental autoimmune uveoretinitis (EAU). C57BL/6 mice were injected daily with AICAR (200 mg/kg, intraperitoneally [IP]) from day 0, the day of interphotoreceptor retinoid-binding protein (IRBP) immunization, until day 21. The severity of uveitis was assessed clinically and histopathologically. T-cell proliferation and cytokine production of IFN-γ, IL-17, and IL-10 in response to IRBP stimulation were determined. In addition, regulatory T-cell (Treg) populations were measured. Co-stimulatory molecule expression (CD40, 80, 86, and I-Ab) on dendritic cells (DCs) in EAU and on bone marrow-derived dendritic cells (BMDCs) treated with AICAR was measured. AICAR treatment significantly reduced clinical and histologic severity of EAU as well as ocular cytokine production. An anti-inflammatory effect associated with the inhibition of T-cell proliferation and Th1 and Th17 cytokine production was observed. Increases in the Th2 response and Treg population were not observed with AICAR treatment. AICAR did significantly inhibit BMDC maturation by reducing co-stimulatory molecule expression. AICAR ...Continue Reading
Citations
Jan 10, 2013·PloS One·Sofia TheodoropoulouDemetrios G Vavvas
Dec 8, 2015·Expert Opinion on Investigational Drugs·Raquel Salazar-MéndezMiguel Cordero-Coma
Dec 3, 2014·Journal of the American Academy of Dermatology·Chun-Ying WuYi-Ju Chen
Nov 7, 2013·Dermato-endocrinology·Hartmut Glossmann, Norbert Reider
Mar 10, 2015·Survey of Ophthalmology·Ping ChenRobert B Nussenblatt
Jan 23, 2016·PloS One·Fumiaki KumaseDemetrios G Vavvas
Oct 7, 2016·International Journal of Immunopathology and Pharmacology·Chethan Gejjalagere Honnappa, Unnikrishnan Mazhuvancherry Kesavan
Dec 17, 2017·Scientific Reports·Eun Jee ChungDemetrios G Vavvas
May 19, 2018·Scientific Reports·Johannes KirchnerDmitry Namgaladze
Jul 29, 2017·Expert Opinion on Pharmacotherapy·Uwe PleyerReinhold Kreutz
Jul 2, 2019·Free Radical Research·Sung Hwan Kim, Jeen-Woo Park
Jan 28, 2020·Immunological Investigations·Beibei WangHongsheng Bi
Nov 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guido A GualdoniGerhard J Zlabinger
Feb 20, 2019·Molecular Reproduction and Development·Jiao Jiao ZhangXian Zhong Wang
Jul 26, 2013·Journal of Leukocyte Biology·Kelly Casey CarrollJill Suttles
Apr 8, 2020·Mediators of Inflammation·Yu ZhaoWei Lin
Jul 28, 2018·Frontiers in Immunology·Wei LinHongsheng Bi
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
Jun 1, 2013·The Journal of Biological Chemistry·Kimio TakeuchiDemetrios G Vavvas
Dec 29, 2020·PloS One·Nikolaos E EfstathiouDemetrios G Vavvas
Mar 9, 2021·Ocular Immunology and Inflammation·Lucia SobrinBrian L VanderBeek
Oct 27, 2017·Journal of Medicinal Chemistry·Kevin R FalesSandaruwan Geeganage