Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.

Investigative Ophthalmology & Visual Science
Jun SuzukiDemetrios G Vavvas

Abstract

To investigate the anti-inflammatory effect of an adenosine monophosphate (AMP) analog, aminoimidazole carboxamide ribonucleotide (AICAR), in experimental autoimmune uveoretinitis (EAU). C57BL/6 mice were injected daily with AICAR (200 mg/kg, intraperitoneally [IP]) from day 0, the day of interphotoreceptor retinoid-binding protein (IRBP) immunization, until day 21. The severity of uveitis was assessed clinically and histopathologically. T-cell proliferation and cytokine production of IFN-γ, IL-17, and IL-10 in response to IRBP stimulation were determined. In addition, regulatory T-cell (Treg) populations were measured. Co-stimulatory molecule expression (CD40, 80, 86, and I-Ab) on dendritic cells (DCs) in EAU and on bone marrow-derived dendritic cells (BMDCs) treated with AICAR was measured. AICAR treatment significantly reduced clinical and histologic severity of EAU as well as ocular cytokine production. An anti-inflammatory effect associated with the inhibition of T-cell proliferation and Th1 and Th17 cytokine production was observed. Increases in the Th2 response and Treg population were not observed with AICAR treatment. AICAR did significantly inhibit BMDC maturation by reducing co-stimulatory molecule expression. AICAR ...Continue Reading

Citations

Dec 8, 2015·Expert Opinion on Investigational Drugs·Raquel Salazar-MéndezMiguel Cordero-Coma
Mar 10, 2015·Survey of Ophthalmology·Ping ChenRobert B Nussenblatt
Oct 7, 2016·International Journal of Immunopathology and Pharmacology·Chethan Gejjalagere Honnappa, Unnikrishnan Mazhuvancherry Kesavan
Dec 17, 2017·Scientific Reports·Eun Jee ChungDemetrios G Vavvas
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