Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydia Coinfections

Antimicrobial Agents and Chemotherapy
Michelle M ButlerTerry L Bowlin

Abstract

Bacterial sexually transmitted infections are widespread and common, with Neisseria gonorrhoeae (gonorrhea) and Chlamydia trachomatis (chlamydia) being the two most frequent causes. If left untreated, both infections can cause pelvic inflammatory disease, infertility, ectopic pregnancy, and other sequelae. The recommended treatment for gonorrhea is ceftriaxone plus azithromycin (to empirically treat chlamydial coinfections). Antibiotic resistance to all existing therapies has developed in gonorrheal infections. The need for new antibiotics is great, but the pipeline for new drugs is alarmingly small. The aminomethyl spectinomycins, a new class of semisynthetic analogs of the antibiotic spectinomycin, were developed on the basis of a computational analysis of the spectinomycin binding site of the bacterial 30S ribosome and structure-guided synthesis. The compounds display particular potency against common respiratory tract pathogens as well as the sexually transmitted pathogens that cause gonorrhea and chlamydia. Here, we demonstrate the in vitro potencies of several compounds of this class against both bacterial species; the compounds displayed increased potencies against N. gonorrhoeae compared to that of spectinomycin and, si...Continue Reading

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Citations

Oct 3, 2018·Antimicrobial Agents and Chemotherapy·Jonathan D LenzJoseph P Dillard
Dec 6, 2019·Medical Microbiology and Immunology·Beata Młynarczyk-BonikowskaSławomir Majewski
Oct 2, 2019·Antimicrobial Agents and Chemotherapy·Marwa AlhashimiMohamed N Seleem
Jun 20, 2018·Antibiotics·Beatriz Suay-García, María Teresa Pérez-Gracia
Jun 6, 2019·The Journal of Antibiotics·Jennifer M ScarffRekha G Panchal
Jan 29, 2021·The Journal of Antibiotics·Suresh DharumanRichard E Lee

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