Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats

Neuroscience
S ZiniC Llorens-Cortès

Abstract

Aminopeptidase A is a membrane-bound zinc metalloprotease which cleaves angiotensin II into angiotensin III. Using a new specific aminopeptidase A inhibitor, EC33, we evaluated its enzymatic activity in several microdissected brain nuclei involved in the control of cardiovascular functions and in the pituitary. We compared this distribution with that of the angiotensin I-converting enzyme which converts angiotensin I to angiotensin II. Aminopeptidase A activity was heterogenously distributed with a 150-fold difference between the lowest and the highest levels. The pituitary and the circumventricular organs were the richest source of enzyme, followed by the median eminence, the arcuate nucleus, the area postrema, the choroid plexus and the supraotic and paraventricular nuclei. We did not find any close parallel between aminopeptidase A and angiotensin I-converting enzyme distributions. We examined both enzymatic activities in brain nuclei of spontaneously hypertensive rats. Aminopeptidase A activity was higher in the spontaneously hypertensive rats than in age-matched Wistar Kyoto control rats. The difference was up to 2.5-fold in several brain nuclei involved in the blood pressure regulation; in contrast, no differences in angi...Continue Reading

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Citations

Jan 5, 2008·Heart Failure Reviews·Laurence BodineauCatherine Llorens-Cortes
Mar 4, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·V B PatelV R Preedy
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·A ReauxC Llorens-Cortes
Sep 1, 1999·Kidney International·A Hus-CitharelC Llorens-Cortes
Jul 12, 2002·Kidney International·Jean-Stéphane PoumaratAnne Blanchard
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ReauxC Llorens-Cortes
Feb 21, 2009·The Journal of Biological Chemistry·Cédric ClaperonCatherine Llorens-Cortes
Dec 28, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hideki ArakawaHreday N Sapru
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claude Fournie-ZaluskiCatherine Llorens-Cortes
Apr 16, 2008·Journal of Neurochemistry·Nadia de MotaCatherine Llorens-Cortes
Jan 16, 2008·Journal of Neuroendocrinology·C Llorens-Cortes, C Kordon
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Mar 8, 2013·Autonomic Neuroscience : Basic & Clinical·Erin L O'CallaghanAndrew M Allen
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Nov 10, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Inmaculada BanegasManuel Ramírez
May 23, 2019·Current Hypertension Reports·Mathilde KeckCatherine Llorens-Cortes
Jul 12, 2001·Experimental Biology and Medicine·A V FergusonK J Latchford
Jan 28, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Mahmoud S AlghamriNadja Grobe
Jul 28, 2013·The Journal of Biological Chemistry·Yang YangFang Li
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·L Juillerat-JeanneretF Pinet
Dec 4, 2019·Hypertension·Catherine Llorens-Cortes, Rhian M Touyz
Sep 22, 2020·The Biochemical Journal·Pierre CouvineauXavier Iturrioz
May 12, 2020·The Canadian Journal of Cardiology·Yannick MarcCatherine Llorens-Cortes
Jul 19, 2011·Progress in Neurobiology·Yannick Marc, Catherine Llorens-Cortes
Jan 2, 2019·Journal of Molecular and Cellular Cardiology·Solène Emmanuelle BoitardCatherine Llorens-Cortes

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