PMID: 33192231Nov 17, 2020Paper

Aminophylline for improving acute kidney injury in pediatric patients: A systematic review and meta-analysis

International Journal of Health Sciences
Saad AlsaadounSultan Al Dalbhi

Abstract

Acute kidney injury (AKI) is a major cause of morbidity and mortality. Whether aminophylline administration can prevent or treat AKI among pediatric patients are not clear. This meta-analysis aimed to assess the efficacy and effectiveness of aminophylline for pediatric AKI. We carried out a systematic search of six databases: PubMed, EMBASE/Excerpta Medica, Scopus, Cochrane library, and Google Scholar from January 1995 up till May 2019. Summary measures of risk ratios and standard mean difference were calculated using the random effects model. We identified seven papers containing data on aminophylline use in children with AKI. Meta-analysis of single-arm studies indicated no statistically significant difference in mean rate of serum creatinine clearance (-0.39 [-0.80-1.58], P = 0.52), mean urine output (1.99 [-1.43-5.42]; P = 0.25), or mean blood urea nitrogen levels (0.83 [-1.86-3.03], P = 0.54) before and after aminophylline administration. However, among double-arm studies, aminophylline administration in the intervention arm significantly reduced the serum creatinine level as compared to control arm (mean diff = -34 [-55.18--12.83]; P = 0.002). Mean urine output (-112.68 [-27.43-48.9], P = 0.17), incidence of AKI (RR = 1.0...Continue Reading

Related Concepts

Related Feeds

Related Papers

Anesthesia and Analgesia
T J Rosko
Anesthesia and Analgesia
J A Stirt, S F Sullivan
Dental Anaesthesia and Sedation
© 2021 Meta ULC. All rights reserved