Aminophylline reduces cardiac ischemic pain during percutaneous transluminal coronary angioplasty

Journal of the American College of Cardiology
T HashinoT Imaizumi

Abstract

We investigated the effect of aminophylline, an antagonist of the adenosine P1 receptor, on cardiac pain experienced during percutaneous transluminal coronary angioplasty (PTCA). Adenosine may mediate cardiac pain because the administration of adenosine provokes cardiac pain like angina. However, it is not known whether endogenous adenosine released during myocardial ischemia is responsible for cardiac pain. This was a single-blind, placebo-controlled randomized study. Of 21 men with stable effort angina with one-vessel coronary artery disease who underwent balloon inflation four times during PTCA, 11 received intravenously administered aminophylline before the fourth balloon inflation and the other 10 were given saline solution. The severity of cardiac pain based on the pain score and ST segment elevation on standard surface and intracoronary electrocardiograms were assessed. All patients experienced cardiac pain during balloon inflation. Aminophylline significantly prolonged the duration of both the symptom-free interval (from 42 +/- 13 to 64 +/- 27 s, mean +/- SD, p < 0.05) and inflation time (from 79 +/- 23 to 103 +/- 20 s, p < 0.05), and it significantly reduced the pain score from 7.6 +/- 1.4 to 4.6 +/- 2.3 (p < 0.01). Ho...Continue Reading

References

Jul 1, 1992·Progress in Cardiovascular Diseases·A MaseriG Davies
Jan 1, 1990·Fundamental & Clinical Pharmacology·V J RichardK A Reimer
Jan 1, 1990·Circulation·F CreaA Maseri
Jan 1, 1989·The American Journal of Cardiology·E PicanoA L'Abbate
Aug 1, 1988·Journal of the American College of Cardiology·M E BertrandI Mirsky
Feb 1, 1986·Circulation Research·H V Sparks, H Bardenheuer
Jul 26, 1986·British Medical Journal·C SylvénR Brandt
Sep 1, 1995·Circulation·T MinaminoM Hori
May 1, 1994·Cardiovascular Research·H J BardenheuerK Peter
Nov 1, 1993·Cardiovascular Drugs and Therapy·C Sylvén
Dec 1, 1993·Journal of the American College of Cardiology·F TomaiP A Gioffrè
Apr 1, 1993·Journal of the American College of Cardiology·G V HellerC E Garber

❮ Previous
Next ❯

Citations

Jan 15, 2009·Journal of Interventional Cardiology·Andy S C YongLeonard Kritharides
Mar 5, 1998·The American Journal of Physiology·H R MiddlekauffJ N Weiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.