PMID: 234264Feb 1, 1975Paper

Aminopyrine--an effective modifier of liver and serum gamma glutamyl transpeptidase

The Journal of Pediatrics
H BartelsI Vogel

Abstract

Serum activities of gamma glutamyl transpeptidase, alanine and aspartate aminotransferases, and alkaline phosphatase were determined in children on long-term treatment with aminopyrine. Gamma glutamyl transpeptidase activity was increased up to 15 times above the upper normal limit in children, who received aminopyrine for two weeks or longer. Livers of rats treated with aminopyrine (600 mg/kg/day for 18 to 25 days) had an exceedingly increased activity of gamma glutamyl transpeptidase and a slightly elevated microsomal cytochrome P-450 content. Apparently isolated enhancement of serum gamma glutamyl transpeptidase during aminopyrine medication represents a drug-induced increase of microsomal liver enzymes without clinical relevance and without evidence of damage of liver cells.

References

Mar 1, 1972·European Journal of Clinical Pharmacology·B SchoeneH F von Oldershausen
Apr 6, 1973·Science·A Meister
Jul 20, 1973·Deutsche medizinische Wochenschrift·F D GauchelG A von Harnack
Sep 19, 1969·Deutsche medizinische Wochenschrift·G SzaszW Fritzsche
Aug 24, 1965·Biochimica Et Biophysica Acta·A Szewczuk, G E Connell

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Citations

Aug 1, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P Colombo, J Colombo
Jan 1, 1980·Addictive Behaviors·E Reyes, W R Miller
Apr 12, 1975·British Medical Journal·H Bartels, H Putzki
May 1, 1985·Environmental Health Perspectives·R W LawtonJ F Brown
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·D M Goldberg
Jan 1, 1982·Anaesthesia·J J Henderson

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