PMID: 234264Feb 1, 1975Paper

Aminopyrine--an effective modifier of liver and serum gamma glutamyl transpeptidase

The Journal of Pediatrics
H BartelsI Vogel


Serum activities of gamma glutamyl transpeptidase, alanine and aspartate aminotransferases, and alkaline phosphatase were determined in children on long-term treatment with aminopyrine. Gamma glutamyl transpeptidase activity was increased up to 15 times above the upper normal limit in children, who received aminopyrine for two weeks or longer. Livers of rats treated with aminopyrine (600 mg/kg/day for 18 to 25 days) had an exceedingly increased activity of gamma glutamyl transpeptidase and a slightly elevated microsomal cytochrome P-450 content. Apparently isolated enhancement of serum gamma glutamyl transpeptidase during aminopyrine medication represents a drug-induced increase of microsomal liver enzymes without clinical relevance and without evidence of damage of liver cells.


Mar 1, 1972·European Journal of Clinical Pharmacology·B SchoeneH F von Oldershausen
Apr 6, 1973·Science·A Meister
Jul 20, 1973·Deutsche medizinische Wochenschrift·F D GauchelG A von Harnack
Sep 19, 1969·Deutsche medizinische Wochenschrift·G SzaszW Fritzsche
Aug 24, 1965·Biochimica Et Biophysica Acta·A Szewczuk, G E Connell

❮ Previous
Next ❯


Aug 1, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P Colombo, J Colombo
Jan 1, 1980·Addictive Behaviors·E Reyes, W R Miller
Apr 12, 1975·British Medical Journal·H Bartels, H Putzki
May 1, 1985·Environmental Health Perspectives·R W LawtonJ F Brown
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·D M Goldberg
Jan 1, 1982·Anaesthesia·J J Henderson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.