Nov 1, 1977

Aminopyrine breath test in alcoholic liver disease and in patients on enzyme-inducing drugs

Journal of Clinical Pathology
K O LewisA Paton


The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs. The normal value for the breath test was 8.6 +/- 1.5%, whereas it was significantly lower (5.1 +/- 3.8%) in patients with alcoholic cirrhosis. Higher than normal values were found in some alcoholic patients without cirrhosis and in patients receiving enzyme-inducing drugs, such as phenobarbitone. There was a significant correlation between serum gamma-glutamyltransferase and breath test in these groups. Some patients with alcoholic cirrhosis may also be capable of enzyme induction.

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Mentioned in this Paper

Breathalyzer Tests
Liver Cirrhosis, Alcoholic
Alcoholic Liver Diseases
Alcohol Abuse
Fibrosis, Liver
Adrenal Cortex Hormones
Enzyme Induction

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