Aminosalicylates

Digestive Diseases
Volker Gross

Abstract

Symptomatic diverticular disease has a high prevalence in countries with a western lifestyle. Besides antibiotics for acute diverticulitis there are no established medical interventions to prevent or to treat symptomatic diverticular disease. Due to its broad spectrum of anti-inflammatory activities, mesalazine is a candidate for the treatment of symptomatic diverticular disease. A review of the literature shows that randomized open studies using various treatment designs suggest a protective role of mesalazine in preventing recurrences of diverticulitis. Currently, 5 randomized placebo-controlled trials are active which will clarify the role of mesalazine to prevent recurrence of diverticulitis in the near future. Several randomized uncontrolled studies suggest that mesalazine improves symptoms in patients with symptomatic uncomplicated diverticular disease. The analysis of secondary end points from two randomized placebo-controlled trials suggests that mesalazine improves symptoms in diverticular disease although both studies failed to show a statistically significant advantage for mesalazine for the primary study end point. In segmental colitis associated with diverticulosis no prospective systematic studies are available. H...Continue Reading

References

Nov 1, 1990·Immunopharmacology·F ShanahanP Anton
Apr 1, 1991·Gut·Y R Mahida
Dec 1, 1987·Digestive Diseases and Sciences·B M PeskarH Goebell
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A TursiR Daffinà
Feb 28, 2004·Lancet·Neil Stollman, Jeffrey B Raskin
Apr 13, 2005·The Journal of Experimental Medicine·Christel RousseauxPierre Desreumaux
May 10, 2005·European Journal of Gastroenterology & Hepatology·M H MuellerMartin E Kreis
Jun 22, 2005·Archives of Surgery·Gregory Broderick-VillaPhilip I Haigh
Aug 4, 2006·Journal of Clinical Gastroenterology·Craig L Floch
Apr 6, 2007·Digestive Diseases and Sciences·Giuseppe ComparatoFrancesco Di Mario
Jun 30, 2009·Journal of Clinical Gastroenterology·Luigi GattaFrancesco Di Mario
Jul 8, 2009·Diseases of the Colon and Rectum·Aaron M MulhallSusan Galandiuk
Aug 27, 2009·The American Journal of Gastroenterology·Kari HemminkiJan Sundquist

❮ Previous
Next ❯

Citations

Jul 7, 2015·Polski przeglad chirurgiczny·Anna PietrzakGrzegorz Wallner
Mar 26, 2016·Terapevticheskiĭ arkhiv·S V LevchenkoL B Lazebnik

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.