PMID: 8583287Nov 1, 1995Paper

Aminosyn PF or trophamine: which provides more protection from cholestasis associated with total parenteral nutrition?

Journal of Pediatric Gastroenterology and Nutrition
M L ForchielliC Lo

Abstract

Cholestasis often occurs in infants on total parenteral nutrition (TPN) for long periods. Amino acid formulations developed specifically for infants, namely Aminosyn PF and Trophamine, may protect against cholestasis associated with total parenteral nutrition (CATPN). The development of cholestasis may also be caused by other risk factors such as prematurity, surgery, sepsis, and extracorporeal membrane oxygenation (ECMO). To evaluate the relative effectiveness of the pediatric amino acid formulations in reducing CATPN, the courses of 70 infants < 1 year of age who received TPN for at least 14 days were reviewed. Cholestasis was defined as a conjugated serum bilirubin > or = 2 mg/dl subsequent to the initiation of TPN; CATPN was considered present when other factors related to cholestasis were ruled out. Liver function tests were recorded 24 h before starting TPN and at day 7, 15, and 21 during TPN infusion. Thirty infants (42.8%) developed cholestasis. CATPN was judged to have occurred in 15 (21.4%) of 70 infants, while 15 (21.4%) developed cholestasis secondary to other factors. Of the 15 CATPN patients, 7 had received Trophamine, 6 had received Aminosyn PF, and 2 had received both solutions. Aminosyn PF and Trophamine, along...Continue Reading

Citations

Jan 23, 1998·Nutrition·K Imura, A Okada
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Olivier GouletVirginie Colomb
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·W C Heird
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Olivier Goulet, Frédérique Sauvat
Jul 27, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·A LevineL Sirotta
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Jul 29, 2005·The Proceedings of the Nutrition Society·William C Heird
Feb 14, 2006·Gastroenterology·Olivier Goulet, Frank Ruemmele
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Michael C Storm, Richard A Helms
Oct 20, 2007·JPEN. Journal of Parenteral and Enteral Nutrition·Jonathan BlauAnupama Chawla
Jun 20, 2001·Pediatric Clinics of North America·J C Haffner, S J Schurman
Aug 13, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph V Ybarra
Feb 14, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·UNKNOWN ASPEN Board of Directors and the Clinical Guidelines Task Force
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·David H Adamkin
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Kelly WrightTara M Burnette

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