Aminotransferases after experimental pneumoperitoneum in dogs

Acta Anaesthesiologica Scandinavica
V Nesek-AdamD Vnuk

Abstract

Laparoscopic surgery has rapidly become a popular and widely used technique. Elevated intra abdominal pressure due to gas insufflation for laparoscopic surgery may result in a number of local and systemic effects on the organism. The effects of pneumoperitoneum on the cardiovascular and respiratory system are well known today, but very few studies have been carried out on the consequences of pneumoperitoneum on hepatic integrity. The aim of the present study was to assess changes in aminotransferases, bilirubin and prothrombin time after pneumoperitoneum in dogs. The effects of different levels and duration of intra abdominal pressure and different gases on liver function test were investigated in dogs. The levels of aspartate aminotransferase, alanine aminotransferase, total and direct bilirubin, and prothrombin time, according to the duration and the level of pneumoperitoneum and gas, were measured at 6, 12, 24 and 48 h of desufflation. The levels of total bilirubin, direct bilirubin and prothrombin time showed no significant alteration. A statistically significant (P < 0.01) elevation of aspartate aminotransferase and alanine aminotransferase was recorded in the group of animals with higher intra abdominal pressure and longe...Continue Reading

References

Nov 1, 1994·Surgical Endoscopy·A J Cunningham
Jul 1, 1994·Surgical Endoscopy·Y HashikuraM Makuuchi
Feb 28, 1998·Surgical Endoscopy·J JakimowiczF Smulders
Aug 26, 1998·Surgical Endoscopy·X Sala-BlanchJ Visa
Sep 9, 1998·The American Journal of Physiology·S A FrenchR S Balaban
Aug 18, 1999·Surgical Endoscopy·C N Gutt, T C Schmandra
May 25, 2002·Acta Anaesthesiologica Scandinavica·L AnderssonS Odeberg-Wernerman

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Citations

Apr 16, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Sascha Santosh ChopraGuido Schumacher
Aug 16, 2015·Surgical Endoscopy·Denise M D Özdemir-van BrunschotMichiel C Warlé

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