PMID: 8445546Feb 1, 1993Paper

Aminotransferases and lactate dehydrogenase in saliva of diabetic patients

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
V MusumeciS Di Salvo

Abstract

Although inflammatory or degenerative changes in salivary glands have been demonstrated in genetic animal models of diabetes mellitus and in experimental diabetes, no information is available in diabetics on the possible leakage in saliva of cytosolic enzymes as markers of salivary cell injury. Aspartate (GOT) and alanine (GPT) aminotransferases and lactate dehydrogenase (LDH) were determined in saliva samples collected by the Salivette method from well-controlled insulin-dependent (IDDM n = 11) and non-insulin-dependent (NIDDM n = 18) diabetic patients and from age-cross-matched healthy subjects (n = 33). In IDDM salivary concentrations of GOT (112.55 +/- 23.94 UI/L) and LDH (1120.27 +/- 168.31 UI/L) were similar to those found in the NIDDM (90.94 +/- 19.64, and 1255.43 +/- 221.40 UI/L respectively), but higher (p < 0.05) than those observed in normal subjects (33.09 +/- 3.71, and 423.58 +/- 39.94, UI/L respectively). GPT was higher in NIDDM than IDDM, which in turn was higher than in normal subjects (42.78 +/- 14.72, 16.45 +/- 3.74 and 6.85 +/- 1.52 UI/L respectively). Salivary and serum values of GOT, GPT and LDH were not correlated. Determination of cytosolic enzymes in saliva may be useful for monitoring the diabetic invol...Continue Reading

References

Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·K Donath, G Seifert
Sep 1, 1975·Journal of Periodontology·M Z MarderI D Mandel
Feb 1, 1991·Diabetes Research and Clinical Practice·B M FisherB M Frier
Jun 1, 1991·Clinical Immunology and Immunopathology·E GoillotJ L Touraine
Sep 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P J LameyB M Frier
Nov 1, 1989·Journal of Dental Research·H Ben-AryehD Laufer
Jan 1, 1986·Archives of Oral Biology·L C Anderson, J R Garrett
Jul 1, 1970·Oral Surgery, Oral Medicine, and Oral Pathology·S ConnerJ Mills
Jan 1, 1969·Annals of Internal Medicine·D DavidsonB Berris
Nov 1, 1983·Journal of Periodontal Research·M Nakamura, J Slots
Dec 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·S B Russotto
Jan 1, 1980·Critical Reviews in Clinical Laboratory Sciences·I D Mandel

❮ Previous
Next ❯

Citations

Jan 31, 2006·Journal of Physiology and Biochemistry·C HirtzDeville de Périère
Dec 25, 2003·Archives of Oral Biology·Víctor Alonso de la PeñaSantiago Rodríguez-Segade
Jun 28, 2012·Revista da Associação Médica Brasileira·Eduardo Buzolin BarbosaEloiza Helena Tajara
Sep 7, 1999·Journal of Periodontology·B Mealey
Apr 14, 2010·Biomarkers in Medicine·Craig S MillerJohn T McDevitt
Mar 27, 2009·Archives of Oral Biology·C HannigM Hannig
Jun 15, 2007·Archives of Oral Biology·Víctor Alonso De La PeñaRafael Tojo Sierra
Jun 1, 2010·Archives of Oral Biology·Mariana Ferreira LeiteRosemari Otton
Aug 5, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J H MeurmanM Uusitupa
Mar 11, 2015·Clinical Oral Investigations·Elżbieta PaszynskaChristian Hannig
May 23, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M VermaA Soni
Apr 30, 2011·The Journal of Physical Chemistry. B·Katarzyna Świderek, Piotr Paneth
Nov 29, 2016·Medicine·Barbara MalickaUrszula Kaczmarek
Nov 19, 2005·Proteomics·Christophe HirtzDominique Deville de Périère
Aug 1, 1999·Journal of Periodontology·UNKNOWN Research, Science and Therapy Committee of The American Academy of Periodontology
Oct 17, 2020·Clinical Oral Investigations·Prem K SreenivasanYogitha Setty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.