PMID: 109082Mar 1, 1979

Aminotripeptidase, a cytosol enzyme from rabbit intestinal mucosa

The Biochemical Journal
C Doumeng, S Maroux

Abstract

Aminotripeptidase, a cytosol enzyme from rabbit intestinal mucosa, was purified to homogeneity. The pure enzyme is a glycoprotein containing a very small amount of sugar. It is composed of only one subunit of 50,000 mol. wt. and possesses 1 zinc atom per molecule. Its specificity is primarily directed towards tripeptides with an N-terminal proline residue. However, the enzyme is also able to hydrolyse other tripeptides, except those with either a charged amino acid in the N-terminal position or a proline residue in the second position. The purified aminotripeptidase accounts for almost all the tripeptidase activity of the soluble fraction from intestinal mucosa.

Related Concepts

Aminopeptidase
Sugars
Cytoplasmic Matrix
Edetic Acid, Sodium Salt
SDS-PAGE
Structure of Intestinal Gland
Substrate Specificity
Zinc

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