Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation

The New England Journal of Medicine
Paul DorianAiala Barr

Abstract

Lidocaine has been the initial antiarrhythmic drug treatment recommended for patients with ventricular fibrillation that is resistant to conversion by defibrillator shocks. We performed a randomized trial comparing intravenous lidocaine with intravenous amiodarone as an adjunct to defibrillation in victims of out-of-hospital cardiac arrest. Patients were enrolled if they had out-of-hospital ventricular fibrillation resistant to three shocks, intravenous epinephrine, and a further shock; or if they had recurrent ventricular fibrillation after initially successful defibrillation. They were randomly assigned in a double-blind manner to receive intravenous amiodarone plus lidocaine placebo or intravenous lidocaine plus amiodarone placebo. The primary end point was the proportion of patients who survived to be admitted to the hospital. In total, 347 patients (mean [+/-SD] age, 67+/-14 years) were enrolled. The mean interval between the time at which paramedics were dispatched to the scene of the cardiac arrest and the time of their arrival was 7+/-3 minutes, and the mean interval from dispatch to drug administration was 25+/-8 minutes. After treatment with amiodarone, 22.8 percent of 180 patients survived to hospital admission, as c...Continue Reading

Associated Clinical Trials

Aug 10, 2021·Simone Savastano

References

Aug 1, 1986·Journal of the American College of Cardiology·P DorianR A Winkle
May 1, 1995·Journal of Cardiovascular Pharmacology·J F AupetitG Faucon
Jan 1, 1994·Journal of the American College of Cardiology·M I Anastasiou-NanaS D Moulopoulos
Sep 16, 1999·The New England Journal of Medicine·P J KudenchukT Walsh
Apr 26, 2001·The New England Journal of Medicine·M S Eisenberg, T J Mengert

❮ Previous
Next ❯

Citations

Sep 25, 2008·JAMA : the Journal of the American Medical Association·Graham NicholUNKNOWN Resuscitation Outcomes Consortium Investigators
Apr 25, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·H-J Trappe
Aug 18, 2006·Der Anaesthesist·V WenzelUNKNOWN European Resuscitation Council
Feb 8, 2005·Der Internist·T KlingenhebenS Fichtlscherer
Feb 1, 2005·Der Internist·C Stellbrink
Jul 19, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Heinz GoegeleinHartmut Ruetten
Aug 3, 2010·Heart and Vessels·Harumichi NakagawaItsuo Kodama
Jul 6, 2005·Herzschrittmachertherapie & Elektrophysiologie·T Klingenheben
Nov 26, 2010·Herzschrittmachertherapie & Elektrophysiologie·C Sohns, M Zabel
Aug 10, 2002·Current Cardiology Reports·Bramah N Singh
Aug 15, 2003·Current Cardiology Reports·Andrea Sarkozy, Paul Dorian
Feb 15, 2005·The Journal of Emergency Medicine·Matthew R LewinNaoki Aikawa
Jun 16, 2005·Resuscitation·David C Cone, Robert E O'Connor
Jun 5, 2003·European Journal of Pharmacology·Shinobu MatsuiMichael L X Fu
Nov 20, 2003·Resuscitation·Anouk P van AlemRudolph W Koster
Jan 18, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Linda R PetersonJoseph G Rogers
Jan 22, 2003·Emergency Medicine·Simone E Taylor
Aug 2, 2002·The New England Journal of Medicine·Tom Silfvast, Ville Pettilä
Dec 13, 2005·The New England Journal of Medicine·Keith A Marill, Patrick T Ellinor
May 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Scott T YoungquistJohn P Rosborough
Aug 2, 2006·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Jodi H Fugate
May 23, 2006·Critical Care Medicine·William E Dager
Dec 20, 2007·Critical Care Medicine·Tessie W OctoberUNKNOWN National Registry of Cardiopulmonary Resuscitation Investigators
Dec 17, 2009·JAAPA : Official Journal of the American Academy of Physician Assistants·David J Klocko
Oct 21, 2010·Critical Care Medicine·Jonathan P PicciniJohn H Alexander
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Masaki IgarashiNobuya Koyama
Dec 7, 2011·Emergency Medicine International·Andry Papastylianou, S Mentzelopoulos
Oct 5, 2011·Circulation·Lance B BeckerUNKNOWN Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation
Aug 14, 2013·Critical Care : the Official Journal of the Critical Care Forum·Yu HuangLei Zhan
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshio TaharaSatoshi Umemura
Sep 3, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoru YusuHideaki Yoshino
Sep 30, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi YasudaUNKNOWN J-PULSE Investigators
Mar 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yosuke MiwaHideaki Yoshino
Jun 17, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Haruaki Nakaya
Sep 18, 2008·Interactive Cardiovascular and Thoracic Surgery·Boudewijn P J LeeuwenburghJoel Dunning

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.