Amiodarone Discontinuation or Dose Reduction Following Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease

JACC. Clinical Electrophysiology
Jackson J LiangDavid S Frankel

Abstract

This study sought to examine long-term outcomes in patients with structural heart disease in whom amiodarone was reduced/discontinued after ventricular tachycardia (VT) ablation. VT in patients with structural heart disease increases morbidity and mortality. Amiodarone can decrease VT burden, but long-term use may result in organ toxicities and possibly increased mortality. Catheter ablation can also decrease VT burden. Whether amiodarone can be safely reduced/discontinued following ablation remains unknown. We studied consecutive patients undergoing VT ablation from 2008 to 2011, typically followed by noninvasive programmed stimulation several days later. Patients were divided into 3 groups by amiodarone use: group A-amiodarone reduced/discontinued following ablation; group B-amiodarone not reduced; group C-not on amiodarone at time of ablation. Baseline characteristics and outcomes were compared between groups. Overall, 231 patients (90% male; mean age: 63.4 ± 12.9 years; 53.7% ischemic cardiomyopathy) were included (group A: 99 patients; group B: 29 patients; group C: 103 patients). Group B patients were older with more advanced heart failure. Group A patients less frequently had inducible VT at the end of ablation or noninv...Continue Reading

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Citations

Jul 15, 2017·World Journal of Cardiology·Daniele MuserJackson J Liang
May 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Edmond M CroninUNKNOWN ESC Scientific Document Group
Apr 25, 2020·Journal of Cardiovascular Electrophysiology·Antonio FronteraPaolo Della Bella
Jul 20, 2017·F1000Research·Syeda Atiqa BatulRakesh Gopinathannair
May 22, 2019·Journal of Cardiovascular Electrophysiology·Jiandu YangDuy T Nguyen
Jan 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Edmond M CroninKatja Zeppenfeld

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