Amiodarone for pharmacological cardioversion of recent-onset atrial fibrillation

International Journal of Cardiology
Ijaz A KhanRamesh M Gowda

Abstract

The efficacy and safety of amiodarone for pharmacological cardioversion of recent-onset atrial fibrillation was examined by reviewing the trials on the subject identified through a comprehensive literature search. Amiodarone has been used both intravenously (i.v.) and orally for the pharmacological cardioversion of recent-onset atrial fibrillation. Intravenous amiodarone has been used as a bolus only or as a bolus followed by a continuous i.v. infusion until conversion or up to 24 h. The dose of i.v. bolus given ranged from 3 to 7 mg/kg body weight and that of infusion from 900 to 3000 mg/day. The efficacy reported is 34-69% with the bolus only regimens, and 55-95% with the bolus followed by infusion regimens. Only the higher dose (>1500 mg/day) amiodarone is superior to placebo in converting recent-onset atrial fibrillation to sinus rhythm. The highest 24-h conversion rates have been reported with the i.v. regimen of 125 mg/h until conversion or a maximum of 3 g and the oral regimen of 25-30 mg/kg body weight administered as a single loading-dose (>90% and >85%, respectively). Most of the conversions occur after 6-8 h of the initiation of therapy. Predictors of successful conversion are shorter duration of atrial fibrillation,...Continue Reading

References

Apr 1, 1992·International Journal of Cardiology·G Vietti-RamusR Latini
Feb 1, 1991·The American Journal of Cardiology·B Strasberg
Apr 1, 1995·The American Journal of Cardiology·K D DonovanK Y Lee
Apr 1, 1996·Journal of the American College of Cardiology·E GalveJ Soler-Soler
Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·G BorianiB Magnani

❮ Previous
Next ❯

Citations

Jul 17, 2008·Herzschrittmachertherapie & Elektrophysiologie·Anil-Martin SinhaMartin Schmidt
Sep 20, 2005·International Journal of Cardiology·Panagiotis KorantzopoulosKonstantinos Siogas
Nov 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Mengalvio E SleeswijkJan G Zijlstra
Oct 11, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Jan 30, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Konstantinos C KoskinasVassileios Vassilikos
May 5, 2012·Heart, Lung & Circulation·Kugathasan Nadarasa, Michael J A Williams
Nov 24, 2011·Thoracic Surgery Clinics·Robert E Merritt, Joseph B Shrager
Jun 13, 2009·Journal of Electrocardiology·Bramah Singh
Aug 8, 2009·Pacing and Clinical Electrophysiology : PACE·James A Reiffel
Feb 13, 2013·Cardiovascular Therapeutics·Enrico VizzardiAntonio Curnis
Feb 3, 2005·International Journal of Cardiology·Panagiotis KorantzopoulosKonstantinos Siogas
Mar 10, 2016·Expert Review of Cardiovascular Therapy·Tuan NguyenPeter Leong-Sit
Apr 5, 2012·Case Reports in Medicine·Anna P KotsiaTheofilos M Kolettis
Aug 1, 2015·Emergency Medicine Clinics of North America·Eric Goralnick, Laura J Bontempo
Jan 15, 2011·Journal of the American College of Cardiology·A John CammUNKNOWN AVRO Investigators
Jun 15, 2016·The Korean Journal of Thoracic and Cardiovascular Surgery·Mohammad Hassan Nemati, Behrooz Astaneh
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Sep 25, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paulus KirchhofKatja Zeppenfeld
Oct 18, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mengqi GongTong Liu
May 16, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Jesse RaitenJacob Gutsche
Jul 2, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Miki Finnin
Jun 5, 2020·Journal of Intensive Care Medicine·Timothy W JonesAndrea Sikora Newsome
Nov 8, 2018·Korean Circulation Journal·Boyoung JoungUNKNOWN KHRS Atrial Fibrillation Guideline Working Group
Jan 25, 2017·Journal of the American Veterinary Medical Association·Mariano Mora PereiraAnne A Wooldridge
Mar 17, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Omar A IbrahimWilliam F McIntyre
Apr 23, 2021·PloS One·Harald HaidlAxel Schlagenhauf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Related Papers

The New England Journal of Medicine
Isabelle C Van GelderRate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group
The New England Journal of Medicine
D G WyseAtrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
© 2022 Meta ULC. All rights reserved