PMID: 3771217Sep 1, 1986Paper

Amiodarone-induced hyperpigmentation

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
L TörökM Szücs

Abstract

Five patients are reported in whom brownish grey discoloration occurred on the light-exposed parts of the dermis after long-term amiodarone-medication. Histological investigation shows that the deposition of lipofuscin in the small veins and perivasal superior part of the corium is responsible for the occurrence of this discoloration. With reference to recent data in the literature, the pathomechanism and prevention of this pigmentation are discussed.

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