PMID: 2507834Jan 1, 1989Paper

Amiodarone-induced pulmonary toxicity in the rat

Lung
B D WilsonM L Lippmann

Abstract

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose. Controls received methyl cellulose alone. Groups of rats were examined after 1, 3, 6, 9, and 12 weeks of feeding. We found that drug-fed rats had significantly more macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage (BAL). The early increase in cellularity was due to an increase in macrophages, and the macrophage count peaked after 6 weeks of drug treatment. The number of neutrophils in the experimental animals remained high throughout the course of the experiment. An increasing number of lymphocytes was seen in the BAL between 6 and 12 weeks of drug treatment. Protein in the lavage fluid was significantly elevated after 12 weeks of amiodarone exposure. Histologic sections were abnormal after 3 weeks of drug treatment, characterized by interstitial thickening with accumulation of mononuclear cells and alveoli packed with large foamy macrophages. There was only minimal evidence of fibrosis. This model appears to be very similar to human amiodarone-induced pulmonary toxicity and should be useful for the study of the pathogenesis of amiodarone...Continue Reading

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Citations

Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·B PadmavathyN Devaraj
Feb 1, 1991·Journal of Paediatrics and Child Health·P D Sly, P N Le Souëf
Apr 1, 1993·Journal of Cardiovascular Electrophysiology·A VereckeiJ Feher
Jun 1, 1990·The American Review of Respiratory Disease·B D Wilson, M L Lippmann
Aug 14, 2002·Drug and Chemical Toxicology·K N S SirajudeenS Niranjali Devaraj
May 29, 2000·Drug and Chemical Toxicology·K N SirajudeenN S Devaraj
Jun 18, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Spyros A PapirisEffrosyni D Manali
Aug 2, 2003·British Journal of Pharmacology·Durairaj PunithavathiMary Babu
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V HainerD B Allison

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