Amiodarone-induced pulmonary toxicity mimicking acute pulmonary edema

Journal of Cardiovascular Medicine
Iacopo FabianiLeonardo Bolognese

Abstract

Amiodarone is a highly effective antiarrhythmic drug. Its long-term use may, however, lead to several adverse effects, with pulmonary toxicity being the most serious. The article presents the case of a 78-year-old woman with a history of cardiac surgery, who after 2 years of amiodarone therapy for prophylactic treatment of atrial fibrillation developed amiodarone pneumonitis mimicking an acute pulmonary edema. The patient failed to respond to diuretic therapy and several courses of anti-infective therapy. Differential diagnosis of different causes of pulmonary infiltrates did not demonstrate any other abnormality. Lung biopsy findings were consistent with the diagnosis of amiodarone pneumonitis. Given the widespread use of amiodarone as an antiarrhythmic agent, pneumologists and cardiologists should consider this important adverse effect as a differential diagnosis of pulmonary distress refractory to therapy in all patients treated with amiodarone who present with respiratory symptoms and pneumonia-like illness.

References

Mar 1, 1992·The American Journal of the Medical Sciences·W D Pitcher
Feb 19, 1987·The New England Journal of Medicine·J W Mason
Nov 1, 1983·Annals of Internal Medicine·M Dan, J Greif
Nov 1, 1983·British Heart Journal·D C RussellA C Douglas
Jul 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·I DimopoulouD V Cokkinos
May 20, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·G A JessurunH J Crijns
Nov 24, 1999·The American Journal of Cardiology·P T Pollak
Aug 21, 2001·European Radiology·H VernhetJ P Senac
Apr 6, 2004·Clinics in Chest Medicine·Philippe CamusEdward C Rosenow
Jun 15, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Nan ChangFu-Tien Chiang
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Patricia Vassallo, Richard G Trohman

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Citations

Mar 8, 2014·Heart and Vessels·Filippo BenassiMarco Meli
Dec 6, 2014·Hospital Pharmacy·Brolin B PooleDebbie C Byrd

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