AMIODARONE-INDUCED THYROTOXICOSIS AFTER TOTAL THYROIDECTOMY FOR METASTATIC FOLLICULAR THYROID CANCER

AACE Clinical Case Reports
Christerlyn Charles, Ketan K Dhatariya

Abstract

To describe the case of a man who developed amiodarone-induced thyrotoxicosis (AIT) after a total thyroidectomy for metastatic follicular thyroid cancer because of the effect of the drug on metastasis. To the best of our knowledge this is the first reported case of this condition. We completed a retrospective review of medical records and laboratory results including thyroid function tests as well as imaging reports including plain radiographs, positron emission tomographs, computed tomographs, and histology reports. A 78-year-old man had undergone a total thyroidectomy for follicular thyroid cancer. He had meta-static disease in his chest and vertebrae, and after the operation he was started on suppressive levothyroxine treatment prior to ablative radioactive iodine treatment. Prior to thyroidectomy, his thyroid-stimulating hormone (TSH) concentration was 3.21 mU/L (reference range is 0.35 to 3.50 mU/L). On suppressive thyroxine replacement, his TSH concentration was 0.02 mU/L, his free thyroxine was 13 pmol/L (reference range is 8 to 12 pmol/L), and free triiodothyronine was 5.8 pmol/L (reference range is 3.8 to 6.0 pmol/L). He subsequently had a myocardial infarction and required antiarrhythmic treatment with amiodarone. Ele...Continue Reading

References

Jul 9, 2009·The Canadian Journal of Cardiology·Wendy Tsang, Robyn L Houlden
Mar 21, 2018·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Mohamed Nabil ElnaggarJoseph M Pappachan
Oct 30, 2018·Journal of the Endocrine Society·Anupam KotwalMarius N Stan

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Citations

Jun 5, 2021·Clinical Case Reports·Vanessa GuerreiroIsabel Torres

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