Amisulpride for the treatment of very-late-onset schizophrenia-like psychosis

International Journal of Geriatric Psychiatry
Constantin PsarrosGeorge N Papadimitriou

Abstract

Although schizophrenia affects all age groups, late or very-late-onset schizophrenia-like psychosis has not been well studied and various treatment issues remain unresolved. The objective of the present study was to evaluate the efficacy and safety of amisulpride monotherapy in a diagnostically homogeneous group of elderly patients without cognitive impairment suffering from very-late-onset schizophrenia. Twenty-six patients of mean age 76.2 +/- 5.8 years, fulfilling both the recent consensus criteria for very late-onset schizophrenia-like psychosis and the DSM-IV-TR criteria for schizophrenia, were assessed by the Brief Psychiatric Rating Scale, the Clinical Global Impression Scale and the Positive and Negative Syndrome Scale at baseline and five weeks following amisulpride (50-200 mg/day) administration; also, the presence of abnormal movements was evaluated with the Simpson-Angus Scale, the Barnes Akathisia Scale, and the Abnormal Involuntary Movement Scale. A highly significant (p < 0.001) improvement on all measures of psychotic symptomatology was observed in all patients. Amisulpride was very well tolerated by the patients and no clinically significant adverse effects were observed. Scores on all abnormal movement scales ...Continue Reading

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Mar 5, 2010·Acta Psychiatrica Scandinavica·I V VahiaDilip V Jeste
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ji Hyun Son, Baik Seok Kee
Aug 12, 2016·BJPsych Bulletin·Chun Chiang Sin Fai LamRobert Howard
Oct 25, 2012·Clinical Oral Implants Research·Irena SailerDavid Schneider
Oct 3, 2014·Journal of Clinical Psychopharmacology·Shani PridanYoram Barak
Oct 11, 2017·Journal of Psychosocial Nursing and Mental Health Services·Elizabeth CortRobert Howard
Dec 7, 2018·Health Technology Assessment : HTA·Robert HowardRichard Gray

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