PMID: 8992021Feb 1, 1996Paper

Amitraz depresses cardiovascular responses to bilateral carotid occlusion

Journal of Veterinary Pharmacology and Therapeutics
J A Reynoldson, L K Cullen

Abstract

The ectoparasiticide amitraz stimulates alpha 2-adrenoceptors to produce side-effects such as bradycardia and hypotension. The actions of amitraz on baroreceptor reflex responses were evaluated in mongrel dogs by occlusion of both carotid arteries for 30-s periods. Incremental doses of amitraz given intravenously showed that doses of 60 micrograms/kg and above significantly depressed pressor responses to carotid occlusion. By comparison, 2 micrograms/kg amitraz given by intracisterna magna (i.c.m.) injection significantly depressed both blood pressure and heart rate responses. Pretreatment of dogs with i.c.m. yohimbine (30 micrograms/kg) prevented the depressant effects of amitraz on the reflex, but prazosin (20 micrograms/kg), in separate experiments, had no effect.

References

Jan 1, 1976·Physiological Reviews·H R Kirchheim
Mar 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·L K Cullen, J A Reynoldson
Jun 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·L K Cullen, J A Reynoldson
Jun 1, 1971·The Journal of Physiology·D E Donald, A J Edis
May 22, 1981·European Journal of Pharmacology·A M HuchetH Schmitt

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