Amitriptyline accumulation and elimination in Calliphora vicina larvae

The American Journal of Forensic Medicine and Pathology
D W SadlerD J Pounder

Abstract

Calliphora vicina larvae reared on artificial foodstuffs spiked with human equivalent therapeutic (100 ng/g), toxic (300 ng/g), lethal (500 ng/g), and 10 x lethal (5,000 ng/g) concentrations of amitriptyline and nortriptyline, alone and in various combinations, were harvested at various stages of development and analysed for drug content by high-pressure liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). Mean (range) larval amitriptyline concentrations (ng/g) in larvae reared on foodstuffs containing 100 ng/g, 500 ng/g, and 5,000 ng/g amitriptyline were 3.21 (<1-5.72), 21.3 (14.2-27.4), and 50.1 (38.8-64.3), respectively, on day 5; 6.62 (5.98-7.72), 22.5 (16.4-32.4), and 38 (22.8-50.9) on day 8; and 4.45 (3.45-5.93), 25.2 (18.6-38.4), and 26.2 (22.7-29.7) on day 11. Nortriptyline concentrations (ng/g) in larvae reared on foodstuffs containing 100 ng/g, 500 ng/g, and 5,000 ng/g nortriptyline were 6.86 (4.48-8.96), 14.1 (11.9-17.8), and 18.5 (16.7-20.6), respectively, on day 5; 8.32 (4.9-11.7), 12.9 (11.5-14.2), and 18.8 (11.5-23) on day 8; and 5.06 (3.27-7.25), 19.4 (17.8-22.4), and 26.6 (11.7-44.7) on day 11. Among 45 separate larval rearings fed on the same foodstuff, mean larval weight ranged from ...Continue Reading

References

Mar 1, 1992·The Journal of Nursing Administration·A S Blouin, N J Brent
Oct 1, 1991·Journal - Forensic Science Society·D J Pounder
Feb 28, 1995·Forensic Science International : Synergy·D W SadlerD J Pounder
Jun 1, 1993·The American Journal of Forensic Medicine and Pathology·Z WilsonD J Pounder

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Citations

Jul 18, 2001·Forensic Science International : Synergy·F IntronaM L Goff
Jul 18, 2001·Forensic Science International : Synergy·B BourelD Gosset
Feb 16, 2011·Forensic Science International : Synergy·Matthias GosselinPierre Rasmont
Jan 18, 2011·Forensic Science International : Synergy·Matthias GosselinBenoit Bourel
Dec 11, 2008·Journal of Forensic Sciences·Helena G OliveiraArício X Linhares
Mar 10, 2016·Anais Da Academia Brasileira De Ciências·Adriana C P FerrazValéria M Aguiar
May 23, 2020·Journal of Medical Entomology·Luz Alejandra Castillo-AlanisMaría Elena Bravo-Gómez

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