journal cover

Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain

Brain Research

Sep 15, 2004

J L ReynoldsR N Spengler

Abstract

The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the cent...read more

Mentioned in this Paper

Necrosis
Exertion
Amines
Tumor Necrosis Factor-alpha
Neurotransmitter Secretion
Neurons
Serotonin
Antagonist Muscle Action
Brain
Uptake
Paper Details
References
  • References13
  • Citations7
12

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

Functional Connectivity Networks

Functional connectivity networks represent specific patterns of synchronous activity and differ between healthy subjects, stages of consciousness and across disease. Discover the latest research on functional connectivity networks here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Lymphopenia

Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. Here is the latest research.


Neuronal Identity

Neuronal identity is important for defining the end result of stem cell differentiation through neuronal developmentor for regenerative medicine. This could involved transcription factors used to drive induce pluripotent stem cells towards the neuronal lineage. Discover the latest research on Neuronal Identity here.

Serotonin

Serotonin is a multifaceted neurotransmitter with various functions, including reward and learning. Discover the latest research, including the latest computational studies, of serotonin here.

Formation of Synapses and Circuits

Synapses are crucial for the transmission of information within neural circuits. These specialized intercellular junctions are the basis for the formation of complex networks. Formation of these synapses involve numerous steps that are essential for transmission of information. Here is the latest research on formation of synapses and circuits.

© 2020 Meta ULC. All rights reserved

Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain

Brain Research

Sep 15, 2004

J L ReynoldsR N Spengler

PMID: 15364025

DOI: 10.1016/j.brainres.2004.07.028

Abstract

The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the cent...read more

Mentioned in this Paper

Necrosis
Exertion
Amines
Tumor Necrosis Factor-alpha
Neurotransmitter Secretion
Neurons
Serotonin
Antagonist Muscle Action
Brain
Uptake

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

Related Papers

Paper Details
References
  • References13
  • Citations7
12
/papers/amitriptyline-administration-transforms-tumor/15364025