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Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain

Brain Research

Oct 8, 2004

Jessica L ReynoldsRobert Nicholas Spengler

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Abstract

The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the cent...read more

Mentioned in this Paper

Amitriptyline
Anser species
Tumor Necrosis Factor Production
Respiratory, Thoracic and Mediastinal Disorders
Desipramine
Amitriptyline Hydrochloride
Wiskott-Aldrich Syndrome
Recombinant Tumor Necrosis Factor Family Protein
MRNA Expression
Structure of Locus Ceruleus
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Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain

Brain Research

Oct 8, 2004

Jessica L ReynoldsRobert Nicholas Spengler

PMID: 15364025

DOI: 10.1016/j.brainres.2004.07.028

Abstract

The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the cent...read more

Mentioned in this Paper

Amitriptyline
Anser species
Tumor Necrosis Factor Production
Respiratory, Thoracic and Mediastinal Disorders
Desipramine

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