PMID: 6104533Aug 4, 1980Paper

Amitriptyline: long-term treatment elevates alpha-adrenergic and muscarinic receptor binding in mouse brain

Brain Research
M RehaviM Sokolovsky

Abstract

The effects of long-term treatment of the tricyclic antidepressant drug, amitriptyline, on alpha-adrenergic, muscarinic and dopaminergic receptor binding were studied in mouse brain. No changes could be observed after 7 or 14 days of amitriptyline administration, but after 21 days a two-fold increase in alpha-adrenergic binding was detected in the medulla pons and in the hippocampus using [3H]WB-4101 as the binding ligand. In the same two regions, a moderate increase in muscarinic receptor binding (25%) as measured by [3H]4NMPB was seen, while no change was detected in dopaminergic receptor binding measured by [3H]spiperone. Scatchard analysis reveals that the increases in receptor densities are not a result of changes in the dissociation constants of the tritiated drugs for their receptors. It is suggested that the increase in alpha-adrenergic as well as in muscarinic binding is a consequence of a chronic blockade of these two types of receptors by amitriptyline in vivo.

References

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Sep 1, 1977·Biochemical Pharmacology·M RehaviM Sokolovsky
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Citations

Jan 1, 1981·Journal of Neural Transmission·K KraeuchiH Feer
Dec 8, 2010·Journal of Neural Transmission·D Ramakrishna, M N Subhash
Apr 1, 1987·Biological Psychiatry·S C DilsaverN E Alessi
Aug 13, 1982·European Journal of Pharmacology·R SabanS De Moraes
Jan 28, 1983·European Journal of Pharmacology·D B MenkesD W Gallager
May 18, 1987·Life Sciences·J F LipinskiC M Waternaux
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·C H Beck, H C Fibiger
Sep 1, 1986·Brain Research·S C Dilsaver
Oct 1, 1989·Brain Research. Brain Research Reviews·S C Dilsaver
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C Dilsaver, R Davidson
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C Dilsaver
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C DilsaverR K Davidson
Sep 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C DilsaverR K Davidson
Aug 2, 2003·Neurochemistry International·M N SubhashK Y Vinod
Feb 13, 2007·The Journal of Pharmacology and Experimental Therapeutics·Jean D DeupreeDavid B Bylund
Jun 22, 2002·Gut·J Fioramonti, L Bueno
Feb 1, 1989·Acta Psychiatrica Scandinavica·S C Dilsaver
Jul 1, 1985·British Journal of Pharmacology·L Choudhury, J M O'Donnell

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