Amlodipine improves endothelial function and metabolic parameters in patients with hypertension

International Journal of Cardiology
Kwang Kon KohEak Kyun Shin

Abstract

Reciprocal relationships between endothelial dysfunction and insulin resistance imply that improvement in endothelial dysfunction will have beneficial metabolic consequences. We hypothesized that amlodipine therapy in hypertensive subjects will improve endothelial dysfunction and metabolic parameters. Amlodipine (10 mg daily for 8 weeks) or placebo was given to each 45 patients with mild to moderate hypertension in a randomized, double-blind, placebo-controlled, and parallel study. Age, sex, and body mass index were matched. Amlodipine therapy significantly reduced systolic and diastolic blood pressure and increased HDL-cholesterol to greater extent than placebo therapy (all P<0.001). Amlodipine therapy significantly improved flow-mediated dilator response to hyperemia and reduced plasma malondialdehyde levels to a greater extent than placebo (P<0.001 and P=0.035). Amlodipine therapy significantly increased plasma adiponectin levels (P=0.009) and decreased plasma leptin and resistin levels (P<0.001 and P=0.025, respectively) to a greater extent than placebo. Correlations were noted between percent changes in adiponectin levels and percent changes in HDL-cholesterol (r=0.348, P=0.019) and QUICKI (r=0.326, P=0.029) following amlo...Continue Reading

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Citations

Feb 11, 2011·Clinical and Experimental Pharmacology & Physiology·Xi HeWei-Jin Zang
Jun 4, 2014·AIDS Research and Human Retroviruses·Gretchen E VolpeAlexandra Mangili
May 16, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lin-Chau ChangWei-Shiung Yang
Nov 26, 2010·International Journal of Cardiology·Kwang Kon KohEak Kyun Shin
Mar 6, 2010·American Journal of Hypertension·Costas TsioufisChristodoulos Stefanadis
Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi
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Jun 28, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Boris HanselAnatol Kontush
Mar 2, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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