PMID: 9536505Apr 16, 1998Paper

Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo

Scandinavian Cardiovascular Journal : SCJ
J RossinenM S Nieminen

Abstract

In order to assess additional anti-ischaemic effects of amlodipine (AML) on coronary artery disease (CAD) treated with beta-blockers, 32 patients with CAD, verified on angiograms, and stable angina were randomized to receive 5 mg/day of AML or placebo, increasing to 10 mg/day after 2 weeks. Baseline recording of 24-h ambulatory ECG and blood pressure, echocardiography and bicycle exercise test was repeated after treatment for 2 weeks and for 6 weeks. Reduction of ambulatory ischaemia was not significantly greater with AML than with placebo. In exercise tests the time to 0.1 mV ST segment depression and the total exercise time remained unaltered. Blood pressure was reduced by 10 mg AML. The total variability and the very low frequency component of heart rate were reduced after both doses. The clinical significance of the possible unfavourable change in autonomic modulation of the heart in CAD patients is not known.

References

Aug 1, 1991·European Heart Journal·H Reichmann, R Gold
Apr 1, 1984·Journal of the American College of Cardiology·M TolinsG L Pierpont
Jan 1, 1993·European Journal of Clinical Pharmacology·P A WoodmanseyK S Channer
Aug 1, 1993·Clinical Cardiology·P C DeedwaniaR C Pasternak

❮ Previous
Next ❯

Citations

Aug 5, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Robert P NolanJohn S Floras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.