Amlodipine/benazepril combination therapy for hypertensive patients nonresponsive to benazepril monotherapy

American Journal of Hypertension
Steven G Chrysant, George L Bakris

Abstract

Most patients with hypertension require two or more antihypertensive medications to achieve blood pressure (BP) goals. This double-blind study compared the efficacy and safety of high-dose combinations of amlodipine besylate (5 mg and 10 mg) and benazepril hydrochloride (40 mg) to benazepril hydrochloride (40 mg) alone in hypertensive patients not adequately controlled with benazepril hydrochloride (40 mg) monotherapy. After a 2-week washout period and a 4-week lead-in period with benazepril 40 mg daily, patients with a mean sitting diastolic BP > or =95 mm Hg (i.e., nonresponders to benazepril 40 mg) were randomly assigned to active treatment with either a combination of amlodipine 5 mg and benazepril 40 mg for 4 weeks followed by a forced titration to amlodipine 10 mg and benazepril 40 mg for an additional 4 weeks, or to benazepril 40 mg alone for 8 weeks. The mean reduction in sitting BP from baseline (on benazepril) to endpoint (after 8 weeks of treatment) was 17/14 mm Hg with amlodipine/benazepril and 5/7 mm Hg with benazepril (P <.0001). The percentage of patients who met the diastolic BP response criteria (<90 mm Hg at endpoint or > or =10 mm Hg decrease from baseline) was 80% in the amlodipine/benazepril group and 45% i...Continue Reading

Citations

May 30, 2009·Vascular Health and Risk Management·Gianpaolo ReboldiPaolo Verdecchia
Oct 11, 2008·The Journal of Clinical Hypertension·Steven G Chrysant
Mar 21, 2009·Therapeutic Advances in Cardiovascular Disease·Jan Basile
Aug 10, 2007·Current Hypertension Reports·Thor TejadaBarry J Materson
Oct 9, 2008·Clinical Drug Investigation·Steven G Chrysant
Oct 24, 2007·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Dean J KereiakesRobert Dubiel
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Steven G Chrysant

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