Amlodipine/valsartan/hydrochlorothiazide: fixed-dose combination in hypertension

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Emma D Deeks

Abstract

Amlodipine/valsartan/hydrochlorothiazide (HCTZ) is a fixed-dose combination of the well established antihypertensive agents amlodipine (a calcium channel antagonist), valsartan (an angiotensin II receptor antagonist), and HCTZ (a thiazide diuretic). In patients with moderate or severe hypertension, triple combination therapy with amlodipine + valsartan + HCTZ produced significantly greater reductions from baseline in mean sitting systolic and diastolic BP (msSBP and msDBP) than either valsartan + HCTZ, amlodipine + HCTZ, or amlodipine + valsartan in a large, 8-week, randomized, double-blind, multinational, phase III trial. Furthermore, the proportion of patients achieving overall BP control at endpoint was significantly greater with the triple combination regimen than with any of the dual regimens, with significantly more triple combination recipients achieving msSBP and msDBP control at each assessment throughout the trial. Subgroup analyses of this study suggested that amlodipine + valsartan + HCTZ was generally more effective in reducing BP and providing overall BP control than the dual combination therapies, irrespective of age, race, gender, ethnicity, or hypertension severity. Several smaller studies provide data that sup...Continue Reading

References

Mar 16, 2001·Expert Opinion on Pharmacotherapy·P A Thürmann
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
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Citations

Apr 22, 2010·Vascular Health and Risk Management·Maurizio DestroPaola Preti
Sep 18, 2012·Current Medical Research and Opinion·Sverre E KjeldsenLisheng Liu
Jun 12, 2013·Journal of the American Society of Hypertension : JASH·Ayesha SalahuddinBarry J Materson
Jan 19, 2012·Expert Opinion on Pharmacotherapy·Ilse M Espina, Joseph Varon
Jun 29, 2011·Current Opinion in Nephrology and Hypertension·Ivana Lazich, George L Bakris

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