Ammonia concentrations in arterial blood, venous blood, and cerebrospinal fluid of dogs with and without congenital extrahepatic portosystemic shunts

American Journal of Veterinary Research
Matan OrHilde de Rooster

Abstract

OBJECTIVE To compare ammonia concentrations in arterial blood, venous blood, and CSF samples of dogs with and without extrahepatic portosystemic shunts (EHPSS). ANIMALS 19 dogs with congenital EHPSS and 6 healthy control dogs. PROCEDURES All dogs underwent a physical examination and then were anesthetized for transsplenic portal scintigraphy to confirm the presence or absence of EHPSS. While dogs were anesthetized, arterial and venous blood samples and a CSF sample were simultaneously collected for determination of ammonia concentration, which was measured by use of a portable blood ammonia analyzer (device A) and a nonportable biochemical analyzer (device B). Results were compared between dogs with EHPSS and control dogs. RESULTS Arterial, venous, and CSF ammonia concentrations for dogs with EHPSS were significantly greater than those for control dogs. For dogs with EHPSS, ammonia concentrations in both arterial and venous blood samples were markedly increased from the reference range. There was a strong positive correlation between arterial and venous ammonia concentrations and between blood (arterial or venous) and CSF ammonia concentrations. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that blood and CSF ammonia con...Continue Reading

References

Feb 2, 1979·Brain Research·M D Norenberg, A Martinez-Hernandez
Mar 1, 1979·The Journal of Clinical Investigation·A H LockwoodF Plum
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A H LockwoodW H Wong
Feb 1, 1987·Neurochemical Pathology·M D Norenberg
Jul 4, 2001·Journal of Neuroscience Research·J Albrecht, M Dolińska
Aug 13, 2002·American Journal of Veterinary Research·David E HoltMichael B Robinson
Sep 5, 2002·Progress in Neurobiology·Vicente Felipo, Roger F Butterworth
Mar 15, 2003·The American Journal of Medicine·Janus P OngKevin D Mullen
Nov 7, 2003·Neurochemistry International·Peter Ott, Fin Stolze Larsen
Nov 24, 2004·Metabolic Brain Disease·Alan H Lockwood
Feb 24, 2005·New Zealand Veterinary Journal·C J BroomeJ A Braddock
May 5, 2005·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Federica MorandiGregory B Daniel
Jan 7, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Shidow TorisuHiromitsu Orima
Aug 10, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William BernalJulia Wendon
Sep 21, 2007·Brain Research Reviews·Laurène Cagnon, Olivier Braissant
Jun 7, 2008·Veterinary Clinical Pathology·Robert GoggsDez Hughes
Jul 27, 2010·Biochemical Pharmacology·Jan AlbrechtMichael D Norenberg
Aug 13, 2010·Nature Reviews. Gastroenterology & Hepatology·Ravi Prakash, Kevin D Mullen
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Saul W BrusilowArthur J L Cooper
Oct 31, 2012·Journal of Inherited Metabolic Disease·Olivier BraissantCristina Cudalbu
Aug 27, 2014·American Journal of Veterinary Research·Inés CarreraMatthias Dennler

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Citations

Apr 27, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Sharon DeMorrowChristopher F Rose

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