Ammonia functions as a regulatory molecule to mediate adjustments in glomerular filtration rate in response to changes in metabolic rate

Medical Hypotheses
M A Singer

Abstract

In mammals, varying in size from mouse to elephant there is a close linkage between metabolic rate (MR) and glomerular filtration rate (GFR). This linkage has evolved because of the necessity to excrete nitrogenous wastes generated predominately by amino acid catabolism. A similar linkage is observed in birds, reptiles and fish, although in the latter vertebrate group gill excretion rate and GFR need to be considered as an interdependent co-ordinated system. A change in the rate of amino acid catabolism will result in a change in the rate of production of nitrogenous wastes requiring excretion and hence GFR (or GFR plus gill excretory rate in fish) must be appropriately re-set. It is hypothesized that ammonia functions as a regulatory molecule to mediate adjustments in excretory rate (GFR or GFR plus gill excretory rate) in response to such changes in amino acid catabolism.

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Citations

Feb 2, 2018·Journal of Biosocial Science·Fatos Selita, Yulia Kovas
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A Singer
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Klaus W Beyenbach
Nov 25, 2020·Zoology : Analysis of Complex Systems, ZACS·Bárbara Silva LinharesMariella Bontempo Freitas
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Michael A Singer
Jun 27, 2019·Journal of the American Chemical Society·Zheng MengKatherine A Mirica

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