Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Larissa Daniele BoberminCarlos-Alberto Gonçalves

Abstract

Ammonia is a key toxin in the precipitation of hepatic encephalopathy (HE), a neuropsychiatric disorder associated with liver failure. In response to ammonia, various toxic events are triggered in astroglial cells, and alterations in brain glutamate communication are common. Resveratrol is a polyphenolic compound that has been extensively studied in pathological events because it presents several beneficial effects, including some in the central nervous system (CNS). We previously described that resveratrol is able to significantly modulate glial functioning and has a protective effect during ammonia challenge in vitro. In this study, we addressed the mechanisms by which resveratrol can protect C6 astroglial cells from glutamatergic alterations induced by ammonia. Resveratrol was able to prevent all the effects triggered by ammonia: (i) decrease in glutamate uptake activity and expression of the EAAC1 glutamate transporter, the main glutamate transporter present in C6 cells; (ii) increase of glutamate release, which was also dependent on the activation of the Na(+)-K(+)-Cl(-) co-transporter NKCC1; (iii) reduction in GS activity and intracellular GSH content; and (iv) impairment of Na(+)K(+)-ATPase activity. Interestingly, resve...Continue Reading

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Citations

Dec 10, 2015·Neurotoxicity Research·Larissa Daniele BoberminAndré Quincozes-Santos
Feb 7, 2017·Nutritional Neuroscience·Larissa Daniele BoberminAndré Quincozes-Santos
Oct 6, 2017·Molecular Neurobiology·Camila Leite SantosAndré Quincozes-Santos
Mar 14, 2020·Neurochemical Research·Mehran TaherianArumugam R Jayakumar
Jan 11, 2017·Molecular and Cellular Biochemistry·Bernardo Assein ArúsLarissa Daniele Bobermin
Jun 17, 2020·Molecular Neurobiology·Larissa Daniele BoberminAndré Quincozes-Santos
Oct 21, 2020·Cellular and Molecular Neurobiology·Larissa Daniele BoberminAndré Quincozes-Santos
Jul 28, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Susana Rivera-MancíaSergio Montes
Sep 29, 2021·Molecular Neurobiology·André Quincozes-SantosLarissa Daniele Bobermin
Feb 20, 2017·Advanced Drug Delivery Reviews·Huaifa Zhang, Jake E Barralet

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