Ammonium [11 C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

MedChemComm
Tom HaywoodPhilip W Miller

Abstract

Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammonia. The [11C]SCN- ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction.

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Citations

Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Carlotta Taddei, Victor W Pike
Jan 11, 2020·The Journal of Organic Chemistry· QumruddeenChandra Bhushan Tripathi

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Methods Mentioned

BETA
imaging technique

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