Amnestic effect of cocaine after the termination of its stimulant action

Progress in Neuro-psychopharmacology & Biological Psychiatry
S T NiigakiR Frussa-Filho

Abstract

The effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. The effects of a single administration of cocaine on memory were investigated during the presence of its motor stimulating effect or just after its termination. The plus-maze discriminative avoidance task (PM-DAT) was used because it provides simultaneous information about memory, anxiety and motor activity. In Experiment I, mice received saline, 7.5, 10, 15 or 30 mg/kg cocaine 5 min before the training session. In Experiment II, mice were trained 30 min after the injection of saline, 7.5, 10, 15 or 30 mg/kg cocaine. In Experiment III, mice received 30 mg/kg cocaine 30 min pre-training and pre-test. In Experiment IV, mice received 30 mg/kg cocaine immediately post-training. Tests were always conducted 24 h following the training session. Given 5 min before training, cocaine promoted a motor stimulant effect at the highest dose during the training session but did not impair memory. When cocaine was injected 30 min pre-training, the drug did not modify motor activity, but produced marked amnestic effects at all doses tested. This amnesia indu...Continue Reading

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Citations

Jun 26, 2012·Psychopharmacology·Karina A ZaninRoberto Frussa-Filho
Mar 27, 2012·Behavioural Brain Research·Valéria S FernandesRegina H Silva
Feb 14, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leandro SandayRoberto Frussa-Filho
Mar 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·André de Macêdo MedeirosRegina Helena Silva
Apr 3, 2013·Psychoneuroendocrinology·André L Takatsu-ColemanRoberto Frussa-Filho
Dec 24, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·F TalhatiR Frussa-Filho
Feb 1, 2013·The International Journal of Neuropsychopharmacology·Leandro SandayRoberto Frussa-Filho
Jun 22, 2012·The International Journal of Neuropsychopharmacology·Leandro SandayRoberto Frussa-Filho
Feb 2, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·M SabeS Kaiser

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