Amnion and collagen-based blended hydrogel improves burn healing efficacy on a rat skin wound model in the presence of wound dressing biomembrane.

Bio-medical Materials and Engineering
Md Masud RanaSikder M Asaduzzaman

Abstract

A burn wound is one of the most frequent and devastating injuries for patients which requires extensive care. Early treatment of burn wounds improves healing significantly. This study was designed to investigate the efficacy of amnion and collagen-based hydrogels on cutaneous burn wound healing in rats with covering membrane. We prepared a novel cell free hydrogel comprising human amnion, rabbit collagen, carboxymethyl cellulose sodium salt, citric acid, methyl paraben, propyl paraben, glycerin and triethanol amine. The wound covering membrane was developed from rabbit collagen and prawn shell chitosan. Beside swelling ratio, water absorption, equilibrium water content, gel fraction and spreadability analysis, in vitro cytotoxicity and biocompatibility tests were performed for the formulated hydrogels. Following the skin irritation study, second-degree burns were created on the dorsal region of the rats and the gels were applied with/without covering membrane to study the wound contraction and re-epithelialization period. The formulated hydrogels were observed non-cytotoxic and compatible with human blood cells. No erythema and edema were found in skin irritation assay confirming the safety and applicability. Hydrogel consistin...Continue Reading

References

Apr 10, 2003·Ophthalmology Clinics of North America·Thomas John
Sep 1, 2007·Advances in Skin & Wound Care·Jaimie T ShoresSubhas Gupta
May 17, 2011·Journal of Cutaneous and Aesthetic Surgery·Onkar SinghRaj Kumar Mathur
Aug 4, 2011·Expert Review of Anti-infective Therapy·Tianhong DaiMichael R Hamblin
Aug 20, 2011·Burns : Journal of the International Society for Burn Injuries·Afshin Rahmanian-SchwarzOliver Lotter
Sep 21, 2011·Journal of Pediatric Surgery·Aaron P LesherAndre V Hebra
Jun 19, 2012·Journal of Biomedical Materials Research. Part a·M Nuruzzaman KhanMubarak A Khan
Aug 13, 2013·International Journal of Pharmaceutics·Tian DaiZibin Gao
Aug 15, 2014·Environmental Health and Toxicology·Jonghye ChoiKwangsik Park
Feb 13, 2015·Plastic and Reconstructive Surgery. Global Open·Heidi DebelsWayne Morrison
Mar 23, 2015·International Journal of Biological Macromolecules·Mourad JridiMoncef Nasri
Aug 23, 2016·Frontiers in Physiology·Laura E Dickinson, Sharon Gerecht
Mar 21, 2017·Journal of International Society of Preventive & Community Dentistry·Ranjana MohanMohan Gundappa
Aug 31, 2017·Scientific Reports·Reham F El-KasedM M Elmazar
Sep 25, 2017·Stem Cells Translational Medicine·Sean V MurphyAnthony Atala
Nov 17, 2017·Scientific Reports·Chung-Ju YehShu-Huei Wang
Nov 17, 2017·Nature·Tobias HirschMichele De Luca
Aug 7, 2018·Burns : Journal of the International Society for Burn Injuries·Ahmad OryanBehrooz Nikahval
Aug 30, 2018·British Journal of Community Nursing·Kiran Dhaliwal, Nicholas Lopez
May 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gregor KravanjaMaja Leitgeb
Jun 5, 2019·BMC Complementary and Alternative Medicine·Md Shaifur RahmanSikder M Asaduzzaman
Aug 31, 2019·Clinics in Podiatric Medicine and Surgery·Thanh Dinh, Casey Lewis

❮ Previous
Next ❯

Citations

Jul 8, 2020·Materials·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Dec 23, 2020·Journal of Biomaterials Applications·Tiago Akira Tashiro AraujoAna Renno
Feb 2, 2021·Frontiers in Bioengineering and Biotechnology·Fatemeh Dadkhah TehraniAzadeh Shabani
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Aleksandar JanevMateja Erdani Kreft

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Medical Journal
A D Redmond
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Zhijun ZhuJing Zhao
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns
Z R Gao
© 2021 Meta ULC. All rights reserved