Amnion Membrane in Diabetic Foot Wounds: A Meta-analysis

Plastic and Reconstructive Surgery. Global Open
Alexandra M HaughJoseph F Buell

Abstract

Amniotic membrane is tissue obtained from human placenta rich in cytokines, growth factors, and stem cells that possess the ability to inhibit infection, improve healing, and stimulate regeneration. A meta-analysis was performed examining randomized controlled trials comparing amniotic tissue products with standard of care in nonhealing diabetic foot ulcers including PubMed, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews. A search of 3 databases identified 596 potentially relevant articles. Application of selection criteria led to the selection of 5 randomized controlled trials. The 5 selected randomized controlled trials represented a total of 311 patients. The pooled relative risk of healing with amniotic products compared with control was 2.7496 (2.05725-3.66524, P < 0.001). The current meta-analysis indicates that the treatment of diabetic foot ulcers with amniotic membrane improves healing rates in diabetic foot ulcers. Further studies are needed to determine whether these products also decrease the incidence of subsequent complications, such as amputation or death, in diabetic patients.

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Citations

Sep 1, 2017·Reproductive Sciences·Louis MarcellinJean Gogusev
Aug 22, 2018·Regenerative Medicine·Bahareh AbbaspanahSeyed Hadi Mousavi
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Jan 1, 2021·Drugs·Danielle Dixon, Michael Edmonds
Oct 16, 2021·Expert Opinion on Drug Discovery·Evelina VågesjöMia Phillipson

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Methods Mentioned

BETA
amputations
amputation

Software Mentioned

Epifix

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