Amniotic fluid alpha-fetoprotein, gamma-glutamyltranspeptidase, and autosomal trisomies.

Prenatal Diagnosis
M ZeituneM A Ferguson-Smith

Abstract

Alpha-fetoprotein (AFP) concentration and gamma-glutamyltranspeptidase (GGT) activity have been analysed in amniotic fluid from a series of 65 pregnancies with autosomal trisomies. AFP values were reduced on average to 60 per cent of normal in cases of trisomy 21, but were not significantly different from normal in cases of trisomies 18 and 13. GGT activities were uniformly lower (44 per cent of normal) for all types of autosomal trisomy. A review of the literature indicates that over 85 per cent of Down's pregnancies but only 39 per cent of trisomy 18 and 13 pregnancies have amniotic fluid AFP levels below the normal median value, while the corresponding figures for GGT are 91 per cent for Down's syndrome and 96 per cent for trisomies 18 and 13.

References

Nov 1, 1985·American Journal of Obstetrics and Gynecology·R O DavisA Milunsky
Feb 1, 1986·American Journal of Obstetrics and Gynecology·T A DoranT Capello
Jun 28, 1986·Lancet·S R JonesG McMahon
Sep 1, 1987·Prenatal Diagnosis·R H LindenbaumJ Keenan
Apr 1, 1988·British Journal of Obstetrics and Gynaecology·S R JonesL Gillan
May 1, 1988·Prenatal Diagnosis·B F CrandallS Perdue
Feb 2, 1985·Lancet·H S CuckleJ Jonasson
Mar 1, 1985·Prenatal Diagnosis·D A AitkenM A Ferguson-Smith
Nov 1, 1986·Prenatal Diagnosis·M PotierL Dallaire
Apr 1, 1986·British Journal of Obstetrics and Gynaecology·D D JonesG F Williams
Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P K BuamahV Davison
Apr 1, 1984·American Journal of Obstetrics and Gynecology·I R MerkatzW E Johnson

❮ Previous
Next ❯

Citations

Nov 12, 2019·Journal of Clinical Laboratory Analysis·Xiaoting LiuChengbin Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.