PMID: 79418Jul 1, 1978

Amniotic fluid alpha-fetoprotein levels and the prenatal diagnosis of neural tube defects: a collaborative study of 2180 pregnancies in the Netherlands

British Journal of Obstetrics and Gynaecology
W J KleijerN J Leschot

Abstract

Amniotic fluid alpha-fetoprotein (AFP) concentrations were measured in 2180 patients at risk of fetal abnormality because of previous history, family history, advanced maternal age, suspected fetal growth retardation and hydramnios. In 12 patients investigated before 20 weeks gestation, pregnancy was terminated because of a raised amniotic fluid AFP-level: 11 fetuses had neural tube defects (NTDs) and one had a congenital nephrosis. There were no false negative results in the 1927 patients tested before 20 weeks and with a pregnancy of known outcome. In patients tested after 20 weeks, the amniotic fluid AFP concentration was raised in 20 cases of anencephaly, in 9 fetuses with severe congenital malformations without NTD and in one apparently normal fetus. Of 428 patients with a previous offspring who had a NTD, only 8(1.9 per cent) again had a fetus with a NTD.

References

Mar 1, 1975·Lancet·H W De Bruijn, H J Huisjes
Apr 1, 1975·British Journal of Obstetrics and Gynaecology·C R StewardJ Lorber
Sep 20, 1975·Lancet·B KjesslerG Jutquist
Jan 1, 1976·British Medical Bulletin·D J Brock
Apr 1, 1976·Journal of Biological Standardization·P Sizaret, S G Anderson
Jun 26, 1976·Lancet·D J Brock, J B Scrimgeour
Sep 1, 1976·The Journal of Pediatrics·J WiggelinkhuizenR O Kaschula
Jul 3, 1976·The Medical Journal of Australia·B FieldC Kerr
Jan 1, 1976·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M Seppälä
Jan 1, 1976·Child: Care, Health and Development·J E Wilkinson, H F Murphy
Jan 1, 1976·Journal of Community Health·E J SalberE J Jackson
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Oct 13, 1973·Lancet·K M LaurenceM Seppala
Oct 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·N C NevinS Nesbitt
Jun 8, 1974·British Medical Journal·M J SellerE D Alberman
Dec 1, 1974·Developmental Medicine and Child Neurology·C O Carter
Jun 15, 1957·Klinische Wochenschrift·E KLEIHAUERK BETKE
Jan 1, 1976·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A A DevarathinamB R Murty

Citations

Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A F Smith
Feb 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N J LeschotH J Coelingh Bennink
Dec 1, 1979·Lancet·G M Raab
Dec 1, 1979·Lancet·G Delle FaveA Kohn
Jan 1, 1981·American Journal of Medical Genetics·N L FisherE Cheng
Jun 24, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroSonia S Hassan

Related Concepts

Alpha-Fetoproteins
Amniocentesis
Amniotic Fluid Index
Aprosencephaly
Acquired Meningomyelocele

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