PMID: 79418Jul 1, 1978

Amniotic fluid alpha-fetoprotein levels and the prenatal diagnosis of neural tube defects: a collaborative study of 2180 pregnancies in the Netherlands

British Journal of Obstetrics and Gynaecology
W J KleijerN J Leschot


Amniotic fluid alpha-fetoprotein (AFP) concentrations were measured in 2180 patients at risk of fetal abnormality because of previous history, family history, advanced maternal age, suspected fetal growth retardation and hydramnios. In 12 patients investigated before 20 weeks gestation, pregnancy was terminated because of a raised amniotic fluid AFP-level: 11 fetuses had neural tube defects (NTDs) and one had a congenital nephrosis. There were no false negative results in the 1927 patients tested before 20 weeks and with a pregnancy of known outcome. In patients tested after 20 weeks, the amniotic fluid AFP concentration was raised in 20 cases of anencephaly, in 9 fetuses with severe congenital malformations without NTD and in one apparently normal fetus. Of 428 patients with a previous offspring who had a NTD, only 8(1.9 per cent) again had a fetus with a NTD.


Mar 1, 1975·Lancet·H W De Bruijn, H J Huisjes
Apr 1, 1975·British Journal of Obstetrics and Gynaecology·C R StewardJ Lorber
Sep 20, 1975·Lancet·B KjesslerG Jutquist
Jan 1, 1976·British Medical Bulletin·D J Brock
Apr 1, 1976·Journal of Biological Standardization·P Sizaret, S G Anderson
Jun 26, 1976·Lancet·D J Brock, J B Scrimgeour
Sep 1, 1976·The Journal of Pediatrics·J WiggelinkhuizenR O Kaschula
Jul 3, 1976·The Medical Journal of Australia·B FieldC Kerr
Jan 1, 1976·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M Seppälä
Jan 1, 1976·Child: Care, Health and Development·J E Wilkinson, H F Murphy
Jan 1, 1976·Journal of Community Health·E J SalberE J Jackson
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Oct 13, 1973·Lancet·K M LaurenceM Seppala
Oct 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·N C NevinS Nesbitt
Jun 8, 1974·British Medical Journal·M J SellerE D Alberman
Dec 1, 1974·Developmental Medicine and Child Neurology·C O Carter
Jun 15, 1957·Klinische Wochenschrift·E KLEIHAUERK BETKE
Jan 1, 1976·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A A DevarathinamB R Murty


Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A F Smith
Feb 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N J LeschotH J Coelingh Bennink
Dec 1, 1979·Lancet·G M Raab
Dec 1, 1979·Lancet·G Delle FaveA Kohn
Jan 1, 1981·American Journal of Medical Genetics·N L FisherE Cheng
Jun 24, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroSonia S Hassan

Related Concepts

Amniotic Fluid Index
Acquired Meningomyelocele

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.