PMID: 9649097Jul 2, 1998Paper

Amniotic fluid complement C3 as a marker of intra-amniotic infection

Obstetrics and Gynecology
A ElimianN Tejani

Abstract

To determine the value of amniotic fluid (AF) complement C3 as a marker of intra-amniotic infection and to compare complement C3 with other rapid markers of intra-amniotic infection. One hundred four women with singleton gestations, in preterm labor with intact membranes, at 23-35 weeks' gestation underwent transabdominal amniocentesis. Amniotic fluid was analyzed for white blood cell (WBC) count, lactate dehydrogenase (LDH), glucose, Gram stain, and complement C3. Cultures for aerobes, anaerobes, and mycoplasma species also were performed. The median values of complement C3, WBC, LDH, and glucose were compared between the culture-positive and -negative groups. Complement C3 was compared with WBC count, LDH, glucose, and Gram stain for sensitivity, specificity, positive and negative predictive values, and accuracy in the prediction of a positive AF culture. Descriptive statistics, receiver operating characteristic curve, Fisher exact test, and Wilcoxon rank-sum test were used for analysis. The prevalence of positive cultures was 11.5% (12 of 104). The culture-positive group had a significantly higher median C3 (7.0 mg/dL) than the median C3 (3.0 mg/dL) of the culture-negative group (P < .001). Also, the median values of WBC (11...Continue Reading

References

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Citations

Aug 25, 2001·Paediatric and Perinatal Epidemiology·R RomeroY M Kim
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
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