PMID: 8955502Nov 1, 1996Paper

Amniotic fluid endothelin-1 levels are increased in pregnancy-induced hypertension and intrauterine growth retardation

American Journal of Reproductive Immunology : AJRI
R Di IorioE V Cosmi

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor released by vascular endothelium. Because endothelial cell damage is considered determinant in the pathophysiology of pregnancy-induced hypertension (PIH), this study was conducted to evaluate the role of ET-1 produced by feto-placental tissues in PIH. Amniotic fluid samples obtained by amniocentesis from patients with PIH (N = 33), intrauterine growth retardation (IUGR) (N = 16), and PIH associated with IUGR (N = 12) were evaluated for ET-1 and compared to 42 normotensive pregnancies using a specific radioimmunoassay. ET-1 levels were significantly increased in PIH (35.6 +/- 1.9 pg/ml) and IUGR groups (33.8 +/- 4.6 pg/ml) compared to controls (20.8 +/- 1.4 pg/ml) (P < 0.01). In patients with PIH associated with IUGR, ET-1 concentrations were higher (P < 0.05) with no correlation with the severity of IUGR. Our data indicate that in PIH and IUGR ET-1 production and/or secretion is enhanced in the amniotic compartment, suggesting that the peptide may contribute to the pathophysiologic modification observed in these conditions.

References

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Citations

Apr 25, 2009·Indian Journal of Pediatrics·Mohamed Al-Shahat NezarMohammad Saleh Al-Haggar
Feb 12, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M ArslanO Himmetoglu
Dec 5, 1998·Obstetrics and Gynecology·C C Lin, J Santolaya-Forgas
Mar 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R Di IorioE V Cosmi
Sep 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L MargaritD Gumenos
Nov 25, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lavinia MargaritGeorge Decavalas
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·Larry G ThaeteMark G Neerhof
Oct 11, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaSweta Shastri
Oct 17, 1998·Hypertension·R Di IorioE V Cosmi
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·R Di IorioE V Cosmi
Jan 30, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Shaun M KhedunJagdisea Moodley

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