PMID: 9419782Oct 1, 1994Paper

Amniotic fluid interleukin-6 and interleukin-8 levels predict the success of tocolysis in patients with preterm labor

Journal of the Society for Gynecologic Investigation
J R AllbertJ C Morrison

Abstract

To determine whether the levels of the cytokines interleukin-6 (IL-6) and IL-8 in amniotic fluid identify patients with preterm labor who are resistant to tocolysis. Amniocenteses were performed in 23 women with documented preterm labor at 20-32 weeks' gestational age who were treated subsequently with tocolytics. The concentrations of IL-6 and IL-8 in amniotic fluid were determined by double-antibody radioimmunoassay methods using recombinant human IL standards. Of the 23 patients, five failed to respond to tocolysis (four delivered within 48 hours), and of the remaining 18, all delivered more than 9 days after tocolysis was initiated (mean 31 +/- 10 days; range 9-61). In women who had failed tocolysis, discriminatory concentrations of IL-6 and IL-8 were 20 and 15 ng/mL, respectively. Of the patients who had amniotic fluid concentrations higher than these thresholds, all failed tocolysis (100% positive predictive value) and delivered within 6 days. The patients with levels below these discriminatory concentrations had successful tocolysis, and 17 of 18 delivered more than 2 weeks after treatment (95% negative predictive value). The success of tocolysis and thus delivery remote from an episode of preterm labor is associated wit...Continue Reading

References

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Citations

Sep 4, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Min KimBo Hyun Yoon
Jan 6, 2001·Cell Transplantation·S TeradaN Sakuragawa
Nov 30, 2012·Archives of Gynecology and Obstetrics·Tobias WeissenbacherKatrin Karl
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia
Jun 27, 2002·The Journal of Perinatal & Neonatal Nursing·Patricia Sauer Witcher
Mar 12, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Piya ChaemsaithongLami Yeo
Dec 2, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reinaldo FigueroaNergesh Tejani
Aug 2, 2015·American Journal of Obstetrics and Gynecology·Roberto RomeroLeonid Margolis

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